8周高强度间歇训练及补充小檗碱对大鼠心肌缺血再灌注后超声心动图及心电图指标影响的研究

IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS ARYA Atherosclerosis Pub Date : 2022-07-01 DOI:10.22122/arya.2022.26274
Parisa Banaei, Farzad Nazem, Mehrnoosh Sedighi
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摘要

背景:心肌缺血可导致左心室功能障碍和心律失常。本研究旨在探讨缺血再灌注损伤(IRI)大鼠心脏的超声心动图变化和心电图参数。方法:选取雄性Wistar大鼠50只(8 ~ 10周龄),随机分为5组(1组训练、2组补充、3组联合(训练加补充)、4组假药、5组对照组)。高强度间歇训练ý(HIIT)进行8周,每周5次。2、3组大鼠给予小檗碱10 mg/kg。最后,48小时后进行心电图和超声心动图检查。冠脉降支结扎心肌缺血30分钟。结果:5组患者左室收缩期终尺寸(LVSD)、左室舒张期终尺寸(LVDD)ý、缩短心输出量分数、射血分数(EF)、每搏量(SV)、室性心动过速(VT)、室性异位搏(VEBs)发作、室性心动过速(VT)持续时间、心电参数均有显著差异(P≤0.05)。结论:小檗碱的补充和HIIT作为预处理剂,有可能预防心肌IRI后EF升高和分数缩短,心输出量和SV的降低,心律失常的改善。最后,这些变化导致心肌IRI大鼠左室功能增加和死亡率降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Investigation of the effect of 8 weeks of high-intensity interval training and berberine supplementation on some echocardiography and electrocardiogram indices following myocardial ischemia-reperfusion in rats.

Background: Myocardial ischemia leads to left ventricular (LV) dysfunction and cardiac arrhythmia. The present research was conducted with the aim to explore echocardiography changes and electrocardiogram parameters of the hearts of rats with ischemia-reperfusion injury (IRI).

Methods: The study subjects included 50 male Wistar rats) 8-10 weeks), which were divided into 5 groups (1: trained, 2: supplemented, 3: combined (training and supplementation), 4: sham, and 5: control). High-intensity interval training ý(HIIT) was performed for 8 weeks, 5 sessions per week. Rats belonging to groups 2 and 3 received 10 mg/kg berberine. Finally, after 48 hours, electrocardiogram and echocardiography were performed on all rats. Moreover, myocardial ischemia was performed by descending coronary artery ligation for 30 minutes.

Results: There were significant differences between the 5 groups in terms of the volumes and dimensions of LV end-systolic dimension (LVSD), LV end-diastolic dimension (LVDD)ý, fractional shortening cardiac output, ejection fraction (EF), stroke volume (SV), ventricular tachycardia (VT), and ventricular ectopic beats (VEBs) episodes, duration of VTs, and ECG parameters (P ≤ 0.05).

Conclusion: Berberine supplementation and HIIT, as preconditioning agents, can possibly prevent the elevation of EF and fractional shortening, the reduction of cardiac output and SV, and arrhythmia improvement after myocardial IRI. Finally, these changes result in increased LV function and decreased mortality in rats with myocardial IRI.

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ARYA Atherosclerosis
ARYA Atherosclerosis CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
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审稿时长
18 weeks
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