立体定向近距离消融治疗不可切除或不能手术的头颈部肿瘤的回顾性研究。

IF 1.1 4区 医学 Q4 ONCOLOGY Journal of Contemporary Brachytherapy Pub Date : 2022-12-01 DOI:10.5114/jcb.2022.123971
Genghao Zhao, Zhe Wang, Chuang Li, Songbai Chen, Liang Yang, Jinyu Wu, Dong Zhou, Zaishaung Ju, Jun Zhou, Ruoyu Wang
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引用次数: 0

摘要

目的:本研究的目的是评估立体定向近距离消融治疗(SABT)治疗不可切除或不能手术的头颈癌的临床疗效和安全性。材料和方法:本研究回顾性评估2016年10月至2021年10月37例接受SABT治疗的不能切除或不能手术的头颈癌患者的临床资料。评估的变量包括局部疗效、局部控制率(LCR)、总生存率(OS)和放射不良反应。结果:中位随访时间为34个月(5-59个月),6、12、24个月的LCR分别为89.2%、78.2%、69.4%。中位生存时间为16个月[95%可信区间(CI): 10.5-21.5个月],6个月、12个月和24个月的OS率分别为97.3%、70.3%和34.5%。单因素分析结果显示,病理类型和肿瘤总体积(GTV) D90与LCR相关(p < 0.05)。病理类型、GTV D90、年龄、植入部位与OS率相关(p < 0.05)。多因素分析结果显示,病理类型和GTV D90与LCR和OS率显著相关(p < 0.05)。术后放射学不良反应评价显示,7例(18.9%)出现1-2级皮肤反应,4例(10.8%)出现1-2级口腔黏膜反应,无3级及以上不良反应。舌癌患者术后发生舌核脱位3例。结论:SABT治疗不能切除或不能手术的头颈部肿瘤具有良好的局部控制性和轻微的不良反应。此外,与其他治疗方式相比,它安全、可行、微创且副作用少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A retrospective study on unresectable or inoperable head and neck cancers treated with stereotactic ablative brachytherapy.

Purpose: The aim of the present study was to assess the clinical efficacy and safety of stereotactic ablative brachytherapy (SABT) for unresectable or inoperable head and neck cancers.

Material and methods: This study retrospectively assessed clinical data of 37 patients with unresectable or inoperable head and neck cancers treated with SABT from October 2016 to October 2021. Variables evaluated included local efficacy, local control rate (LCR), overall survival (OS) rate, and radiological adverse effects.

Results: The median follow-up was of 34 months (range, 5-59 months), and LCR at 6, 12, and 24 months was 89.2%, 78.2%, and 69.4%, respectively. The median survival time was 16 months [95% confidence interval (CI): 10.5-21.5 months], and the OS rate at 6, 12, and 24 months was 97.3%, 70.3%, and 34.5%, respectively. The results of univariate analysis revealed that the type of pathology and gross tumor volume (GTV) D90 were related to LCR (p < 0.05). However, the type of pathology, GTV D90, age, and implantation site were related to OS rate (p < 0.05). The results of multivariate analysis showed that the type of pathology and GTV D90 were substantially related to LCR and OS rate (p < 0.05). The evaluation of post-operative radiological adverse reactions revealed that seven cases (18.9%) developed grade 1-2 skin reactions, four cases (10.8%) developed grade 1-2 oral mucosal outcomes, and no cases developed grade 3 or higher adverse reactions. Post-operative seed dislocation occurred in three patients with tongue cancer.

Conclusions: SABT has produced good local control and mild adverse reactions in the treatment of unresectable or inoperable head and neck cancers. Additionally, it is safe, feasible, minimally invasive, and has fewer adverse effects than other treatment modalities.

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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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