通过集体细胞迁移共培养细胞模型系统的重排

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-09-30 DOI:10.1016/j.semcdb.2022.10.002
Ivana Pajic-Lijakovic , Raluca Eftimie , Milan Milivojevic , Stéphane P.A. Bordas
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引用次数: 7

摘要

癌症通过周围上皮和细胞外基质(ECM)的侵袭是癌症进展的主要特征之一。尽管人们已经做出了重大努力来预测癌症细胞在各种药物治疗下的反应,但人们很少关注了解癌症细胞与其微环境之间的物理相互作用,这对癌症侵袭至关重要。通过强调粘弹性、组织表面张力、固体应力及其相互关系的作用,考虑到各种共同培养的体外模型系统上的这些物理相互作用,是确定影响癌症细胞扩散的主要因素并制定有效抑制策略的先决条件。这篇综述的重点是由集体细胞迁移(CCM)引起的粘弹性在单培养和共培养癌症系统中的作用,以及旨在复制和理解这些生物系统的建模方法。在这种情况下,我们不仅回顾了先前发表的细胞集体迁移的生物物理学模型,还提出了这些模型的新扩展,以包括球体核心区域内积累的固体应力和CCM引起的细胞残余应力积累。
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The rearrangement of co-cultured cellular model systems via collective cell migration

Cancer invasion through the surrounding epithelium and extracellular matrix (ECM) is the one of the main characteristics of cancer progression. While significant effort has been made to predict cancer cells response under various drug therapies, much less attention has been paid to understand the physical interactions between cancer cells and their microenvironment, which are essential for cancer invasion. Considering these physical interactions on various co-cultured in vitro model systems by emphasizing the role of viscoelasticity, the tissue surface tension, solid stress, and their inter-relations is a prerequisite for establishing the main factors that influence cancer cell spread and develop an efficient strategy to suppress it. This review focuses on the role of viscoelasticity caused by collective cell migration (CCM) in the context of mono-cultured and co-cultured cancer systems, and on the modeling approaches aimed at reproducing and understanding these biological systems. In this context, we do not only review previously-published biophysics models for collective cell migration, but also propose new extensions of those models to include solid stress accumulated within the spheroid core region and cell residual stress accumulation caused by CCM.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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