Ziyaur Rahman, Tahir Khuroo, Eman M Mohamed, Sathish Dharani, Canberk Kayalar, Mathew A Kuttolamadom, Lamba Omar Sangaré, Mansoor A Khan
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引用次数: 0
摘要
目的：本研究的重点是开发氨苄西林（PMT）的印片制剂：本研究的重点是开发嘧霉胺（PMT）的印片制剂：方法：通过筛选设计，改变激光扫描速度、Kollidon® VA 64、聚乙烯吡咯烷酮和崩解剂，研制出氨甲喋呤的小丸配方：结果：激光扫描速度、Kollidon® VA 和崩解剂对硬度、崩解时间和/或溶解度有显著的统计学影响（P 0.05）：结论：印片的临床表现与压缩片相似。
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity.
Objectives: The focus of the present research is to develop printlet formulations of pyrimethamine (PMT).
Methods: Printlets formulation of PMT were developed by screening design by varying laser scanning speed, Kollidon® VA 64, polyvinylpyrrolidone, and disintegrant.
Results: Laser scanning speed, Kollidon® VA, and disintegrant had statistically significant effect on hardness, disintegration time, and/or dissolution (p < 0.05). Dissolution was almost 100% in 30 min. X-ray powder diffraction indicated partial amorphous transformation of the crystalline drug. Pharmacokinetic and anti-toxoplasma activity profiles of the printlets and compressed tablets were superimposable with no statistical difference (p > 0.05).
Conclusion: Clinical performance of the printlets would be similar to the compressed tablets.
期刊介绍：
Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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