精神分裂症谱系障碍患者的神经认知功能与死亡率

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2023-09-01 DOI:10.1016/j.scog.2023.100284
Christine Mohn , Anna-Karin Olsson , Iris van Dijk Härd , Lars Helldin
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引用次数: 0

摘要

精神分裂症谱系障碍患者的预期寿命明显低于健康人。此前,我们已经确定了一般的基线神经认知功能,尤其是语言记忆和执行功能与近20年后的死亡率有关。在这项研究中,我们的目标是用更大的、年龄匹配的样本来复制这些发现。患者组由252人组成,其中44人死亡,206人活着。神经认知是用一个综合的电池来评估的。结果显示,与在世组相比,死亡组在几乎所有领域都有明显更严重的神经认知缺陷。两组之间在性别、缓解状态、精神病症状或功能水平方面没有差异。即时言语记忆和执行功能是生存状态的最强预测因素。这些结果与我们之前的研究几乎相同,我们得出结论,基线神经认知功能是SSD死亡率的重要预测因素。临床医生应该注意有严重认知缺陷的患者的这种关系。
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Neurocognitive function and mortality in patients with schizophrenia spectrum disorders

Individuals with schizophrenia spectrum disorders (SSD) have significantly lower life-expectancy than healthy people. Previously, we have identified baseline neurocognitive function in general and verbal memory and executive function in particular as related to mortality nearly two decades later. In this study, we aim to replicate these findings with a larger and age-matched sample. The patient group consisted of 252 individuals, 44 of whom were deceased and 206 alive. Neurocognition was assessed with a comprehensive battery. Results showed that the deceased group, compared to the living group, had significantly more severe neurocognitive deficits across nearly all domains. There were no differences in sex, remission status, psychosis symptoms, or function level between the groups. Immediate verbal memory and executive function were the strongest predictors of survival status. These results were nearly identical to our previous studies, and we conclude that baseline neurocognitive function is an important predictor for mortality in SSD. Clinicians should be mindful of this relationship in patients with significant cognitive deficits.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
期刊最新文献
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