“哨兵或同谋”:肠-脑相互作用障碍中的肠道微生物群和小胶质细胞相互作用。

IF 13.6 1区 生物学 Q1 CELL BIOLOGY Protein & Cell Pub Date : 2023-10-25 DOI:10.1093/procel/pwad020
Haonan Zheng, Cunzheng Zhang, Jindong Zhang, Liping Duan
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引用次数: 1

摘要

异常的脑-肠相互作用被认为是肠-脑相互作用障碍(DGBI)背后的核心病理机制,肠道微生物群在其中发挥着重要作用。小胶质细胞是中枢神经系统的“哨兵”,参与创伤性脑损伤引起的组织损伤,抵抗中枢感染并参与神经发生,参与各种神经系统疾病的发生。随着对DGBI的深入研究,我们可以发现肠道微生物群和小胶质细胞之间的相互作用,它们共同参与了DGBI的发生,尤其是在患有精神疾病合并症的个体中,如肠易激综合征(IBS)。这种微生物群和小胶质细胞的双向调节为DGBI的治疗提供了新的方向。在这篇综述中,我们重点讨论了肠道微生物群和小胶质细胞之间相互作用在DGBI,特别是IBS中的作用和潜在机制,以及相应的临床应用前景,并强调了其在治疗精神病合并症患者中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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"Sentinel or accomplice": gut microbiota and microglia crosstalk in disorders of gut-brain interaction.

Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction (DGBI), in which the intestinal microbiota plays an important role. Microglia are the "sentinels" of the central nervous system (CNS), which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on DGBI, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome (IBS). This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI, especially IBS, and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities.

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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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