血管内大b细胞淋巴瘤患者与晚期弥漫性大b细胞淋巴瘤患者血清sIL-2R和LDH水平的比较

Yuki Hirami, Midori Filiz Nishimura, Tomohiro Urata, Michiko Morimoto, Yukina Maekawa, Tadashi Yoshino, Yoshito Nishimura, Yasuharu Sato
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引用次数: 2

摘要

血管内大b细胞淋巴瘤(IVL)是一种罕见的淋巴瘤,其特征是肿瘤选择性地在血管内生长。世界卫生组织第五版分类将IVL定义为一种大b细胞淋巴瘤,与弥漫性大b细胞淋巴瘤相同,未另行指定(DLBCL, NOS)。由于IVL的临床表现是非特异性的,诊断非常耗时,而且病程往往是致命的。已知血清可溶性白介素-2受体(sIL-2R)和血清乳酸脱氢酶(LDH)水平在各种淋巴瘤中升高。然而,在b细胞淋巴瘤中sIL-2R升高的机制尚不完全清楚。在本研究中,我们分析了39例IVL患者的血清实验室检查水平,包括sIL-2R和LDH,以及B症状的存在,并将其与56例IV期DLBCL患者进行了比较。IVL患者sIL-2R和LDH水平均显著高于DLBCL患者(p = 0.035和p = 0.002)。在IVL中,有无B症状患者sIL-2R和LDH水平无显著差异(p = 0.206和p = 0.441)。然而,在DLBCL中,存在B症状时sIL-2R和LDH水平均显著升高(p分别= 0.001和p < 0.001)。IVL中sIL-2R和LDH的高水平可能与外周血微环境有关,但需要进一步的研究来验证。
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Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma.

Intravascular large B-cell lymphoma (IVL) is a rare type of lymphoma characterized by tumor growth selectively within the vessels. The 5th edition of the World Health Organization classification defines IVL as a large B-cell lymphoma, the same as diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). Since the clinical manifestations of IVL are nonspecific, the diagnosis is time-consuming, and the course is often fatal. Serum soluble interleukin-2 receptor (sIL-2R) and serum lactate dehydrogenase (LDH) levels are known to be elevated in a variety of lymphomas. However, the mechanism of sIL-2R elevation in B-cell lymphomas is not fully understood. In this study, we analyzed the serum level of laboratory findings, including sIL-2R and LDH, as well as the presence of B symptoms in 39 patients with IVL, and compared them with 56 patients with stage IV DLBCL. Both sIL-2R and LDH levels were significantly higher in IVL than in DLBCL (p = 0.035 and p = 0.002, respectively). In IVL, there were no significant differences in both sIL-2R and LDH levels between patients with and without B symptoms (p = 0.206 and p = 0.441, respectively). However, in DLBCL, both sIL-2R and LDH levels were significantly higher in the presence of B symptoms (p = 0.001 and p < 0.001, respectively). The high sIL-2R and LDH levels in IVL may be related to the peripheral blood microenvironment, but further studies are needed to verify this.

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来源期刊
CiteScore
2.00
自引率
6.70%
发文量
25
审稿时长
11 weeks
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