Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain
{"title":"消除监狱中的丙型肝炎病毒:18 年的经验","authors":"Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain","doi":"10.1016/j.eimce.2023.04.015","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.</p></div><div><h3>Methods</h3><p>Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.</p><p><span>A descriptive analysis of patient characteristics<span> and the response to the three antiviral treatment modalities was performed: peg-interferon and </span></span>ribavirin<span>, peg-interferon, ribavirin<span> and a first-generation protease inhibitor and different combinations of direct-acting antivirals.</span></span></p></div><div><h3>Results</h3><p><span>A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40%–50%). Conversely, in period 3 </span><em>viral breakthroug</em>h (67%) was the main culprit.</p></div><div><h3>Conclusion</h3><p>After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Elimination of hepatitis C virus in a prison: An 18-year experience\",\"authors\":\"Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain\",\"doi\":\"10.1016/j.eimce.2023.04.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.</p></div><div><h3>Methods</h3><p>Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.</p><p><span>A descriptive analysis of patient characteristics<span> and the response to the three antiviral treatment modalities was performed: peg-interferon and </span></span>ribavirin<span>, peg-interferon, ribavirin<span> and a first-generation protease inhibitor and different combinations of direct-acting antivirals.</span></span></p></div><div><h3>Results</h3><p><span>A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40%–50%). Conversely, in period 3 </span><em>viral breakthroug</em>h (67%) was the main culprit.</p></div><div><h3>Conclusion</h3><p>After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.</p></div>\",\"PeriodicalId\":72916,\"journal\":{\"name\":\"Enfermedades infecciosas y microbiologia clinica (English ed.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enfermedades infecciosas y microbiologia clinica (English ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2529993X23001284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades infecciosas y microbiologia clinica (English ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2529993X23001284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Elimination of hepatitis C virus in a prison: An 18-year experience
Introduction
Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.
Methods
Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.
A descriptive analysis of patient characteristics and the response to the three antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.
Results
A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40%–50%). Conversely, in period 3 viral breakthrough (67%) was the main culprit.
Conclusion
After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.