中国骨巨细胞瘤疾病特点及治疗方式的回顾性观察研究。

IF 1.8 Q3 ONCOLOGY Journal of Cancer Epidemiology Pub Date : 2023-01-01 DOI:10.1155/2023/5468291
Hairong Xu, Yuan Li, Tao Wang, Weifeng Liu, Ke Ma, Yongkun Yang, Zhen Huang, Chuang Li, Xiaohui Niu
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引用次数: 0

摘要

目的:骨巨细胞瘤(GCTB)具有相当高的发病率。由于中国的GCTB流行病学数据有限,本研究旨在描述中国GCTB的疾病特征,并在治疗方案取得最新进展之前建立其治疗的历史背景。方法:采用单中心、回顾性、非介入性、观察性研究方法,对2009 - 2016年在北京积水滩医院接受GCTB治疗的患者进行病历复习,评估GCTB的疾病特征、治疗方式及术后局部复发率。未满足需求的患者被定义为那些手术治疗困难或必须接受高发病率手术的患者。结果:668例原发性GCTB患者中,578例(86.5%)病灶位于四肢,89例(13.3%)病灶位于骨盆或轴骨。其中,173个(25.9%)被描述为有未满足的需求。几乎所有的GCTB患者在初次诊断(666/668(99.7%))和最后一次复发(196/200(98.0%))时都接受了手术治疗。此外,约三分之一的患者在初次诊断(205/668(30.7%))和疾病复发(67/200(33.5%))时接受了非手术治疗,新辅助治疗是最常见的治疗方法。复发性疾病的高发病率手术率(65/200(32.5%))高于初次诊断(111/668(16.6%))。术后2年累计疾病复发率为29.2%,与既往研究一致。结论:原发性和复发性疾病患者多为高发病率手术,需要更有效的治疗。
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A Retrospective Observational Study on Disease Characteristics and Treatment Patterns of Giant Cell Tumor of the Bone in China.

Aims: Giant cell tumor of the bone (GCTB) is associated with considerable morbidity. As GCTB epidemiological data for China are limited, this study is aimed at describing the disease characteristics of GCTB in China and establishing the historical context for its treatment before recent advances in treatment options.

Methods: The disease characteristics, treatment patterns, and local GCTB recurrence rate after primary surgery for GCTB were evaluated in this single-center, retrospective, noninterventional, observational study of patients treated for GCTB at Ji Shui Tan Hospital, Beijing, from 2009 to 2016 based on medical chart review. Patients with unmet need were defined as those whose surgical treatment was difficult or who had to undergo high-morbidity surgery.

Results: Among the 668 patients with a primary GCTB diagnosis, 578 (86.5%) of target lesions were in the extremities, and 89 (13.3%) were in the pelvic or axial bone. Of these, 173 (25.9%) were characterized as having an unmet need. Almost all GCTB patients received surgical treatment at both primary diagnosis (666/668 (99.7%)) and last disease recurrence (196/200 (98.0%)). Additionally, about one-third of patients received nonsurgical treatment at primary diagnosis (205/668 (30.7%)) and disease recurrence (67/200 (33.5%)), with neoadjuvant therapy being the most common treatment. The rate of high-morbidity surgery increased for recurrent disease (65/200 (32.5%)) compared with primary diagnosis (111/668 (16.6%)). The 2-year cumulative incidence of postoperative disease recurrence was 29.2%, in line with rates observed in prior studies.

Conclusion: As many patients with primary and recurrent disease received high-morbidity surgery, more effective treatments are needed.

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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
10
审稿时长
20 weeks
期刊介绍: Journal of Cancer Epidemiology is a peer-reviewed, open access journal that publishes original research articles, review articles, case reports, and clinical studies in all areas of cancer epidemiology.
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