含脂滴眼液对全身异维甲酸患者眼表和体内共聚焦显微镜结果的影响。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2023-03-01 DOI:10.1080/15569527.2023.2166523
Ahmet Alp Bilgic, Huri Sabur, Mutlu Acar, Filiz Canpolat
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引用次数: 0

摘要

目的:评价含脂Rohto干法滴眼液和透明质酸钠滴眼液对全身异维甲酸患者眼表和体内共聚焦显微镜(IVCM)检查结果的影响。方法:对71例全身异维甲酸治疗寻常性痤疮患者进行回顾性研究。采用泪液破裂时间(TBUT)、角膜荧光素染色(CFS)和眼表疾病指数问卷(OSDI)评估眼表和泪液功能。mebography用于Meibomian gland dysfunction (MGD)分期,IVCM用于分析角膜微结构变化。记录36例使用Rohto干燥剂(Rohto组)和35例使用透明质酸钠(SH组)患者的数据。分析治疗前、第1个月和第3个月的数据。结果:与SH组相比,Rohto组治疗后1、3个月TBUT延长,OSDI评分降低,CFS减轻(p p > 0.05)。结论:Rohto干眼剂具有脂质层的支持作用,是一种有效、安全的治疗MGD蒸发性干眼症的药物,可改善眼表和IVCM表现。
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Effects of lipid-containing eye drops on the ocular surface and in vivo confocal microscopy findings in patients using systemic isotretinoin.

Objective: To evaluate the effects of lipid-containing Rohto Dry Aid eye drops and sodium hyaluronate eye drops on the ocular surface and in vivo confocal microscopy (IVCM) findings in patients using systemic isotretinoin.

Methods: This retrospective study included 71 patients using systemic isotretinoin for acne vulgaris. Ocular surface and tear functions were evaluated with the tear break-up time (TBUT), corneal fluorescein staining (CFS), and the ocular surface disease index questionnaire (OSDI). Meibography was used for the staging of Meibomian gland dysfunction (MGD) while IVCM was used for the analysis of corneal micro-structural changes. The data of 36 patients using Rohto Dry Aid (the Rohto group) and 35 patients using sodium hyaluronate (the SH group) were recorded. Pre-treatment, first month and third month data were analyzed.

Results: Longer TBUT, lower OSDI score, and less CFS were observed in the first and third months after treatment in the Rohto group (p < 0.001). There was no significant change in TBUT and CFS in the first month (p > 0.05) in the SH group (p < 0.05) but lower TBUT and more CFS were observed in the third month. There was no significant change in the OSDI score in the SH group. There was a significant decrease in dendritic cells, activated keratocytes, and nerve tortuosity with IVCM in both groups. However, no significant difference was found between the two groups.

Conclusion: Rohto Dry Aid, with its support of the lipid layer, is an effective and safe treatment agent that can improve both ocular surface and IVCM findings in evaporative dry eye cases with MGD.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
期刊最新文献
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