Kibong Kim, Kang Pa Lee, Suji Beak, Sunyoung Park, Jisu Kim, Sang Hyun Ahn
{"title":"混合草药改善酒精性胃炎模型胃功能的可行性。","authors":"Kibong Kim, Kang Pa Lee, Suji Beak, Sunyoung Park, Jisu Kim, Sang Hyun Ahn","doi":"10.20463/pan.2023.0001","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.</p><p><strong>Methods: </strong>A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.</p><p><strong>Results: </strong>MAG (10-100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.</p><p><strong>Conclusion: </strong>MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.</p>","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/2f/pan-2023-0001.PMC10164514.pdf","citationCount":"0","resultStr":"{\"title\":\"Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model.\",\"authors\":\"Kibong Kim, Kang Pa Lee, Suji Beak, Sunyoung Park, Jisu Kim, Sang Hyun Ahn\",\"doi\":\"10.20463/pan.2023.0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.</p><p><strong>Methods: </strong>A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.</p><p><strong>Results: </strong>MAG (10-100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.</p><p><strong>Conclusion: </strong>MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.</p>\",\"PeriodicalId\":74444,\"journal\":{\"name\":\"Physical activity and nutrition\",\"volume\":\"27 1\",\"pages\":\"1-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/2f/pan-2023-0001.PMC10164514.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physical activity and nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20463/pan.2023.0001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical activity and nutrition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20463/pan.2023.0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model.
Purpose: Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.
Methods: A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.
Results: MAG (10-100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.
Conclusion: MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.
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