植物源纳米颗粒的最新专利及其在各种癌症治疗中的潜在应用。

IF 2.5 4区 医学 Q3 ONCOLOGY Recent patents on anti-cancer drug discovery Pub Date : 2023-01-01 DOI:10.2174/1574892817666220420122426
S B Santhosh, Santny Shanmugarama, Nimma Ramesh, A Mohamed Sheik Tharik, Veera Vijaya Basamshetty
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引用次数: 1

摘要

背景:纳米技术在医学领域起着至关重要的作用。特别是各种纳米粒子,如银、金、铂,都参与了不同类型癌症的治疗。采用化学、物理、电化学和生物等方法合成了有效的纳米颗粒。为了克服纳米颗粒合成存在的局限性,研究人员将注意力转向了利用植物和植物产物进行生物单步合成纳米颗粒的方法。目的:本研究的目的是克服现有抗癌药物的非特异性和快速排泄等副作用,而植物源性纳米颗粒具有生态友好、经济高效和生物活性,是一种有前景的替代方案。结论:通过对相关文献和近期专利的研究,我们了解到植物源性纳米颗粒在不影响正常细胞的情况下,对不同类型的肿瘤具有良好的抗增殖抗肿瘤活性。特别是,从植物中获得的传统化疗药物与纳米颗粒结合在一起,在抗癌研究中显示出显著的效果。本文综述了一些现有的植物源性纳米颗粒、配方及其在癌症治疗中的潜在应用。
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Recent Patents on Plant-Derived Nanoparticles and their Potential Application Towards Various Cancer Therapeutics.

Background: Nanotechnology plays a vital role in the field of medicine. Especially various nanoparticles such as silver, gold, platinum are involved in the treatment of different types of cancer. The effective nanoparticles were synthesized using techniques like chemical, physical, electrochemical and biological methods. In order to overcome the limitations existing in the synthesis of nanoparticles, researchers turned their attention toward the biological single step nanoparticle synthesis method by using plant and plant products.

Objective: The objective of this study is to overcome the side effects encountered in the existing anti- cancer agents like nonspecificity and fast excretion, and plant-derived nanoparticles that are ecofriendly, cost-effective and biologically active could serve as a promising alternative.

Conclusion: From the thorough literature review and recent patents, it is understood that the plantderived nanoparticles exhibited an excellent anti-proliferation anti-tumor activity towards different types of cancers without affecting the normal cells. Especially, the traditional chemotherapeutic drugs obtained from the plant source incorporated with the nanoparticles show remarkable results against anti cancer studies. The present review focused on some of the existing herbal plant derived nanoparticles, formulations and their potential application in cancer therapeutics.

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来源期刊
CiteScore
4.50
自引率
7.10%
发文量
55
审稿时长
3 months
期刊介绍: Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.
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