元素周期表对生物无机化学的影响及生物对金属离子的选择性利用。

4区 化学 Q3 Chemistry Structure and Bonding Pub Date : 2019-01-01 DOI:10.1007/430_2019_45
Ambika Bhagi-Damodaran, Yi Lu
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引用次数: 1

摘要

尽管元素周期表中有各种各样的金属离子,但生物学只使用几种有选择性的金属离子。大多数氧化还原活性金属在元素周期表中属于第一行过渡金属,包括Fe, Co, Ni, Mn和Cu。另一方面,Ca、Zn和Mg是生物学中最常用的氧化还原活性金属。在本章中,我们通过探索金属生物学选择性选择背后的原因,讨论元素周期表对生物无机化学的影响。一个特别的重点放在化学和功能的原因,为什么一种金属离子优于另一种。我们讨论了金属选择在各种生物过程中的意义,包括催化、电子转移、氧化还原传感和信号传导。我们发现金属离子的生物利用度及其氧化还原电位、配位柔韧性、配价和配体亲和力决定了金属在生物过程中的特异性。了解这些生物过程中元素周期表中金属选择性选择的潜在含义可以帮助设计更有效的催化剂,更精确的生物传感器和更有效的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Periodic Table's Impact on Bioinorganic Chemistry and Biology's Selective Use of Metal Ions.

Despite the availability of a vast variety of metal ions in the periodic table, biology uses only a selective few metal ions. Most of the redox active metals used belong to the first row of transition metals in the periodic table and include Fe, Co, Ni, Mn and Cu. On the other hand, Ca, Zn and Mg are the most commonly used redox inactive metals in biology. In this chapter, we discuss the periodic table's impact on bio-inorganic chemistry, by exploring reasons behind this selective choice of metals biology. A special focus is placed on the chemical and functional reasons why one metal ion is preferred over another one. We discuss the implications of metal choice in various biological processes including catalysis, electron transfer, redox sensing and signaling. We find that bioavailability of metal ions along with their redox potentials, coordination flexibility, valency and ligand affinity determine the specificity of metals for biological processes. Understanding the implications underlying the selective choice of metals of the periodic table in these biological processes can help design more efficient catalysts, more precise biosensors and more effective drugs.

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来源期刊
Structure and Bonding
Structure and Bonding 化学-无机化学与核化学
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期刊介绍: Structure and Bonding is a publication which uniquely bridges the journal and book format. Organized into topical volumes, the series publishes in depth and critical reviews on all topics concerning structure and bonding. With over 50 years of history, the series has developed from covering theoretical methods for simple molecules to more complex systems. Topics addressed in the series now include the design and engineering of molecular solids such as molecular machines, surfaces, two dimensional materials, metal clusters and supramolecular species based either on complementary hydrogen bonding networks or metal coordination centers in metal-organic framework materials (MOFs). Also of interest is the study of reaction coordinates of organometallic transformations and catalytic processes, and the electronic properties of metal ions involved in important biochemical enzymatic reactions.
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