焦虑与冠状动脉微血管功能障碍有关:来自CAMADA研究的结果

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2023-01-12 DOI:10.1111/micc.12798
Ying Li, Weixian Xu, Lijun Guo
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引用次数: 1

摘要

目的冠状动脉微血管功能障碍是缺血性心脏病的重要组成部分。在这里,我们使用冠状动脉微血管功能指标评估焦虑/抑郁与CMD之间的关系。方法纳入非阻塞性冠状动脉疾病患者81例(男26例,女55例)。采用焦虑自评量表和抑郁自评量表对焦虑和抑郁症状进行测量。采用经胸多普勒超声心动图测量冠状动脉血流储备(CFR)评价冠状动脉微血管功能。结果焦虑组CFR明显低于无焦虑组(2.97±0.63∶3.40±0.61,p = 0.029)。在双变量相关分析中,焦虑与CFR呈负相关(r = -)。333, p = .002)。在多元线性回归模型中,在调整了年龄、性别、BMI、高血压、血脂异常、吸烟状况和早发冠心病家族史等因素后,焦虑与CFR呈负相关(β =−)。314, p = .008)。当多元线性回归模型中同时包含焦虑和抑郁时,焦虑也与CFR呈负相关(β =−)。345, p = .012)。结论焦虑患者CFR较低,焦虑与CFR独立相关。心理障碍可能在冠状动脉微血管功能障碍中起重要作用。
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Anxiety is associated with coronary microvascular dysfunction: Results from the CAMADA study

Objective

Coronary microvascular dysfunction (CMD) is an important component of ischemic heart disease. Here, we assessed the associations between anxiety/depression and CMD using coronary microvascular function indicators.

Methods

The study included 81 patients (26 males and 55 females) with nonobstructive coronary artery disease. The symptoms of anxiety and depression were measured with Self-rating Anxiety Scale and Self-rating Depression Scale. Coronary microvascular function was assessed using coronary flow reserve (CFR) measured by transthoracic Doppler echocardiography.

Results

The anxiety group had significantly lower CFR than that in the no-anxiety group (2.97 ± 0.63 vs. 3.40 ± 0.61, p = .029). In bivariate correlation analysis, anxiety was negatively associated with CFR (r = −.333, p = .002). In the multiple linear regression model, after adjusting for age, sex, BMI, hypertension, dyslipidemia, smoking status, and family history of premature coronary heart disease, anxiety was negatively associated with CFR (β = −.314, p = .008). When both anxiety and depression were included in the multiple linear regression model, anxiety was also negatively associated with CFR (β = −.345, p = .012).

Conclusion

Anxiety patients had lower CFR, anxiety was independently associated with CFR. Psychological disorders may play an important role in coronary microvascular dysfunction.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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