口腔扁平苔藓与肝脏疾病和肝细胞癌的关系:系统评价和荟萃分析。

M-Á González-Moles, T de Porras-Carrique, P Ramos-García
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引用次数: 3

摘要

背景:口腔扁平苔藓(OLP)是一种常见的自身免疫性慢性炎症性疾病,病因不明。肝脏疾病和OLP之间关系的重要性在于,许多这些疾病(HC、HB、肝硬化、肝脂肪变性)都是肝细胞癌的危险因素。材料和方法:我们检索了PubMed、Embase、Web of Science和Scopus,检索了2022年1月之前发表的研究。我们评估研究的质量(乔安娜布里格斯研究所工具)。我们进行了荟萃分析,调查了研究之间的异质性,我们还进行了亚组、荟萃回归和小研究效应分析。146项研究(21,187例患者)纳入本研究。我们的研究旨在评估肝脏疾病(特别是那些有恶性肿瘤风险的疾病)、肝细胞癌和OLP之间的患病率和相关性的现有证据。结果:我们的研究结果表明,OLP患者目前乙型肝炎的一个重要发展趋势(或= 1.62,95% ci = 1.01 - -2.40, p = 0.02),丙型肝炎(或= 4.09,95% ci = 2.77 - -6.03, pConclusions: OLP患者应该调查排除肝脏疾病的存在,从而导致肝细胞癌,允许一个早期诊断,有助于更好的方法肝病和显著改善预后方面的进展和严重性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma: systematic review and meta-analysis.

Background: Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology. The importance of the association between hepatic disease and OLP lies in the fact that many of these disorders (HC, HB, cirrhosis, hepatic steatosis) behave as risk factors for hepatocellular carcinoma.

Material and methods: We searched PubMed, Embase, Web of Science, and Scopus for studies published before January 2022. We evaluated the quality of studies (Joanna Briggs Institute tool). We performed meta-analyses, investigated the heterogeneity between studies, and we also carried out subgroups, meta-regression, and small-study effects analyses. 146 studies (21,187 patients) were included in this study. Our study aims to evaluate current evidence on the prevalence and magnitude of association between hepatic diseases (especially those with risk of malignancy), hepatocellular carcinoma and OLP.

Results: Our results suggest that patients with OLP present a significant tendency to the development of hepatitis B (OR=1.62, 95%CI=1.01-2.40, p=0.02), hepatitis C (OR=4.09, 95%CI=2.77-6.03, p<0.001), cirrhosis (OR=5.58, 95%CI=1.83-16.96, p=0.002), hepatic steatosis (OR=5.71, 95%CI=0.97-33.60, p=0.05) and hepatocellular carcinoma (OR=3.10,95%CI=1.14-8.43, p=0.03).

Conclusions: Patients with OLP should be investigated to rule out the presence of hepatic disease, which can lead to hepatocellular carcinoma, allowing an early diagnosis that would help to a better approach to liver disease and a notable improvement in prognosis in terms of both progression and severity.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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