肺炎链球菌靶向异食识别和逃避的分子机制:肺炎球菌作为细胞内细菌的重新解释

IF 1.9 4区 医学 Q4 IMMUNOLOGY Microbiology and Immunology Pub Date : 2023-03-05 DOI:10.1111/1348-0421.13060
Michinaga Ogawa, Sayaka Shizukuishi, Yukihiro Akeda, Makoto Ohnishi
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引用次数: 1

摘要

肺炎链球菌是一种主要的包膜革兰氏阳性病原体,可引起社区获得性肺炎、脑膜炎和败血症等疾病。这种病原体在无症状的情况下定植于鼻咽上皮,但通常可以迁移到无菌组织并引起危及生命的侵袭性感染(侵袭性肺炎球菌病)。虽然多价肺炎球菌多糖和结合疫苗是可用且有效的,但它们在出现疫苗耐药血清型方面也存在重大缺点。因此,需要替代治疗方法,宿主-病原体相互作用的分子分析及其在药物开发和临床实践中的应用近年来受到越来越多的关注。在这篇综述中,我们介绍了参与致病性的肺炎球菌表面毒力因子,并重点介绍了宿主自噬识别机制对细胞内肺炎链球菌和肺炎球菌逃避自噬的最新进展。
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Molecular mechanism of Streptococcus pneumoniae–targeting xenophagy recognition and evasion: Reinterpretation of pneumococci as intracellular bacteria

Streptococcus pneumoniae is a major, encapsulated Gram-positive pathogen that causes diseases including community-acquired pneumonia, meningitis, and sepsis. This pathogen colonizes the nasopharyngeal epithelia asymptomatically but can often migrate to sterile tissues and cause life-threatening invasive infections (invasive pneumococcal disease). Although multivalent pneumococcal polysaccharides and conjugate vaccines are available and effective, they also have major shortcomings with respect to the emergence of vaccine-resistant serotypes. Therefore, alternative therapeutic approaches are needed, and the molecular analysis of host–pathogen interactions and their applications to pharmaceutical development and clinical practice has recently received increased attention. In this review, we introduce pneumococcal surface virulence factors involved in pathogenicity and highlight recent advances in our understanding of host autophagy recognition mechanisms against intracellular S. pneumoniae and pneumococcal evasion from autophagy.

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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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