中国精神分裂症患者自杀意念与神经认知功能之间的性别差异。

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2024-09-01 Epub Date: 2023-05-15 DOI:10.1007/s00406-023-01616-8
Fengchun Wu, Yun Yi, Yunling Lian, Qiang Chen, Lanfang Luo, Hanlun Yang, Hehua Li, Yangdong Feng, Shixuan Feng, Sumiao Zhou, Yuanyuan Huang, Zezhi Li, Xiangyang Zhang
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引用次数: 0

摘要

越来越多的证据表明,精神分裂症患者的许多临床表现都存在性别差异,包括自杀意念(SI)和神经认知功能。本研究旨在探讨中国精神分裂症患者自杀意念与神经认知功能之间的性别差异。本研究从多中心精神病医院共招募了1188名精神分裂症住院患者。采用神经心理状态评估重复性电池(RBANS)对所有患者的神经认知功能进行评估。积极与消极综合征量表(PANSS)用于评估患者的精神病理学。贝克自杀意念量表(BSSI)用于评估 SI 的严重程度。在男性患者中,自杀风险得分与 PANSS 阴性症状(r = 0.167,p = 0.043)、视觉空间分量表(r = - 0.261,p = 0.001)和 RBANS 总分(r = - 0.172,p = 0.037)显著相关。此外,多变量线性回归分析表明,在男性患者中,视觉空间分量表(β = - 0.490,t = - 3.273,p = 0.001)与自杀风险评分独立相关。在女性患者中,自杀风险评分与 PANSS 阳性症状(r = 0.249,p = 0.021)、阴性症状(r = 0.394,p = 0.001)和视觉空间分析分量表(β = - 0.490,t = - 3273,p = 0.001)显著相关。
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Sex differences in the association between suicidal ideation and neurocognitive function in Chinese patients with schizophrenia.

There is increasing evidence that sex differences exist in many clinical manifestations of patients with schizophrenia, including suicidal ideation (SI) and neurocognitive function. The present study was performed to explore the sex differences in the association between SI and neurocognitive function in Chinese patients with schizophrenia. A total of 1188 inpatients with schizophrenia were recruited from multicenter psychiatric hospitals. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was utilized to evaluate the neurocognitive function of all patients. The Positive and Negative Syndrome Scale (PANSS) was utilized to assess the psychopathology of patients. The Beck Scale for Suicide Ideation (BSSI) was used to assess the severity of SI. In male patients, the suicide risk score was significantly associated with PANSS negative symptoms (r = 0.167, p = 0.043), visuospatial subscale (r = - 0.261, p = 0.001), and RBANS total scores (r = - 0.172, p = 0.037). Furthermore, multivariate linear regression analysis showed that the visuospatial subscale (β = - 0.490, t = - 3.273, p = 0.001) was independently associated with the suicide risk score in male patients. In female patients, the suicide risk score was significantly correlated with PANSS positive symptoms (r = 0.249, p = 0.021), negative symptoms (r = 0.394, p < 0.001), general psychopathology (r = 0.276, p = 0.01) and PANSS total score (r = 0.365, p = 0.001). Multivariate linear regression analysis showed that PANSS negative symptoms (β = 1.849, t = 3.933, p = 0.001) were significantly associated with suicide risk scores in female patients. Our findings indicate that there are sex differences in the association between SI and neurocognitive function in patients with schizophrenia. Based on the findings of our study, gender-specific prevention and intervention strategies may make a difference in reducing SI in Chinese schizophrenia patients.

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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
期刊最新文献
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