Jiabu Ye, Dejian Lai, Lemuel A Moye, Barry R Davis
{"title":"协变量调整非参数方法在CCTRN临床试验中的应用。","authors":"Jiabu Ye, Dejian Lai, Lemuel A Moye, Barry R Davis","doi":"10.1080/23737484.2022.2126414","DOIUrl":null,"url":null,"abstract":"<p><p>CCTRN is a Cardiovascular Cell Therapy Research Network. There were three randomized double blinded controlled stem cell clinical trials conducted in its first phase. The main results of these three clinical trials were published with conventional parametric models such as T test and nonparametric test such as Wilcoxon rank sum test without adjusting covariates. In this article, we conducted further analysis of the primary outcomes of these studies using a class of covariate adjusted nonparametric methods.</p>","PeriodicalId":36561,"journal":{"name":"Communications in Statistics Case Studies Data Analysis and Applications","volume":"8 4","pages":"728-737"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181848/pdf/nihms-1847500.pdf","citationCount":"0","resultStr":"{\"title\":\"Applications of Covariate Adjusted Nonparametric Methods to CCTRN Clinical Trials.\",\"authors\":\"Jiabu Ye, Dejian Lai, Lemuel A Moye, Barry R Davis\",\"doi\":\"10.1080/23737484.2022.2126414\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>CCTRN is a Cardiovascular Cell Therapy Research Network. There were three randomized double blinded controlled stem cell clinical trials conducted in its first phase. The main results of these three clinical trials were published with conventional parametric models such as T test and nonparametric test such as Wilcoxon rank sum test without adjusting covariates. In this article, we conducted further analysis of the primary outcomes of these studies using a class of covariate adjusted nonparametric methods.</p>\",\"PeriodicalId\":36561,\"journal\":{\"name\":\"Communications in Statistics Case Studies Data Analysis and Applications\",\"volume\":\"8 4\",\"pages\":\"728-737\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181848/pdf/nihms-1847500.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Communications in Statistics Case Studies Data Analysis and Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23737484.2022.2126414\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"Mathematics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communications in Statistics Case Studies Data Analysis and Applications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23737484.2022.2126414","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/22 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"Mathematics","Score":null,"Total":0}
Applications of Covariate Adjusted Nonparametric Methods to CCTRN Clinical Trials.
CCTRN is a Cardiovascular Cell Therapy Research Network. There were three randomized double blinded controlled stem cell clinical trials conducted in its first phase. The main results of these three clinical trials were published with conventional parametric models such as T test and nonparametric test such as Wilcoxon rank sum test without adjusting covariates. In this article, we conducted further analysis of the primary outcomes of these studies using a class of covariate adjusted nonparametric methods.
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