母婴微生物组:代际健康和营养保健的下一代指标和目标。

IF 13.6 1区 生物学 Q1 CELL BIOLOGY Protein & Cell Pub Date : 2023-11-08 DOI:10.1093/procel/pwad029
Shengtao Gao, Jinfeng Wang
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引用次数: 0

摘要

微生物通常对宿主(包括母亲和婴儿)生理和病理状态的变化很敏感。从这个角度来看,微生物组可能是怀孕期间疾病的一个很好的指标,并有可能用于围产期健康监测。体现在多体点微生物组辅助诊断、早期预测、长期监测、孕婴并发症回顾性诊断以及母婴营养管理和保健品开发等方面。在此,我们总结了这些领域的研究进展,并解释了不同身体部位的微生物组对不同的疾病敏感,它们的微生物生物标志物可能相互重叠,因此我们需要对这些疾病进行谨慎的诊断。根据微生物组差异和额外的人体测量和物理数据,可以预测母亲和新生儿对膳食和益生菌/益生元的个性化反应,这对于精确的营养和益生菌/益生元管理和发展具有重要意义。虽然在以往的研究中表现出了很多令人鼓舞的效果,但未来可以通过多组学和时间序列分析等多方面的数据来进一步提高疗效。这篇综述从微生物组的角度重新定义了母婴健康,其中的知识可能会激发新的选择,以预防和治疗不良妊娠结局,并带来围产期保健的飞跃。
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Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care.

Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts, including mothers and babies. From this perspective, the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health monitoring. This is embodied in the application of microbiome from multi body sites for auxiliary diagnosis, early prediction, prolonged monitoring, and retrospective diagnosis of pregnancy and infant complications, as well as nutrition management and health products developments of mothers and babies. Here we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other, thus we need to make a diagnosis prudently for those diseases. Based on the microbiome variances and additional anthropometric and physical data, individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable, which is of importance for precise nutrition and probiotics/prebiotics managements and developments. Although a great deal of encouraging performance was manifested in previous studies, the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the future. This review reconceptualizes maternal and infant health from a microbiome perspective, and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.

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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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