{"title":"来自NSP7的肽能够形成淀粉样蛋白样原纤维:人工产物还是对药物设计的挑战?","authors":"Yuri Garmay , Aleksandr Rubel , Vladimir Egorov","doi":"10.1016/j.bbapap.2022.140884","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>•</span><span><p>We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein <em>in silico</em></p></span></li><li><span>•</span><span><p>NSP7 (52–62) fragment is able to form amyloid-like fibrils</p></span></li><li><span>•</span><span><p>The possibility of using such a peptide as the basis for an antiviral drug is discussed</p></span></li></ul></div>","PeriodicalId":8760,"journal":{"name":"Biochimica et biophysica acta. Proteins and proteomics","volume":"1871 2","pages":"Article 140884"},"PeriodicalIF":2.3000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711895/pdf/","citationCount":"1","resultStr":"{\"title\":\"Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?\",\"authors\":\"Yuri Garmay , Aleksandr Rubel , Vladimir Egorov\",\"doi\":\"10.1016/j.bbapap.2022.140884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>•</span><span><p>We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein <em>in silico</em></p></span></li><li><span>•</span><span><p>NSP7 (52–62) fragment is able to form amyloid-like fibrils</p></span></li><li><span>•</span><span><p>The possibility of using such a peptide as the basis for an antiviral drug is discussed</p></span></li></ul></div>\",\"PeriodicalId\":8760,\"journal\":{\"name\":\"Biochimica et biophysica acta. Proteins and proteomics\",\"volume\":\"1871 2\",\"pages\":\"Article 140884\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711895/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et biophysica acta. Proteins and proteomics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1570963922001315\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/12/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Proteins and proteomics","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1570963922001315","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
期刊介绍：
BBA Proteins and Proteomics covers protein structure conformation and dynamics; protein folding; protein-ligand interactions; enzyme mechanisms, models and kinetics; protein physical properties and spectroscopy; and proteomics and bioinformatics analyses of protein structure, protein function, or protein regulation.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
