Laura A Welke, Tara L Moore, Douglas L Rosene, Ronald J Killiany, Mark B Moss
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As a surgical control group, a second set of animals, the ipsilateral frontal-hippocampal split group, was prepared with a <i>unilateral</i> lesion of the DLPFC and an <i>ipsilateral</i> H + lesion together plus transection of the corpus callosum and anterior commissure. This preparation matches the locus and extent of damage in the cross-lesion group but allows the intact H + and intact DLPFC to interact ipsilaterally. Following recovery from surgery, all animals were then tested on the delayed nonmatching to sample task (DNMS), a test of recognition memory. The crossed-lesion split-brain group (CFHS) was markedly impaired on DNMS in both acquisition (rule learning) and performance over delays (recognition memory). The results provide evidence of a functionally dependent interaction between the medial temporal lobe and the dorsolateral prefrontal cortex in learning and memory. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 3","pages":"211-222"},"PeriodicalIF":1.6000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192048/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prefrontal and medial temporal interactions in memory functions in the rhesus monkey.\",\"authors\":\"Laura A Welke, Tara L Moore, Douglas L Rosene, Ronald J Killiany, Mark B Moss\",\"doi\":\"10.1037/bne0000556\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Both the medial temporal lobe and the dorsolateral prefrontal cortex have been implicated in learning and memory. However, it has been difficult to ascertain the degree to which the two structures are dependent on each other or interact in subserving these cognitive functions. 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引用次数: 0
摘要
内侧颞叶和背外侧前额叶皮层都与学习和记忆有关。然而,人们一直难以确定这两种结构在多大程度上相互依赖或相互作用,从而为这些认知功能服务。为了直接研究这个问题,我们准备了两组猴子。首先,对侧额叶-海马分裂组(CFHS)接受单侧海马及周围后部海马旁皮层(H +)损伤,同时对侧背外侧前额叶皮层(DLPFC)进行损伤,并横断胼胝体和前裂。这种制备方法在功能上 "断开 "了对侧半球剩余完整的 H + 与唯一完整的 DLPFC 的联系。作为手术对照组,第二组动物(同侧额叶-海马分裂组)的制备方法是单侧 DLPFC 损伤和同侧 H + 损伤以及胼胝体和前裂横断。这种制备方法与交叉损伤组的损伤位置和程度一致,但允许同侧完好的 H + 和完好的 DLPFC 相互作用。手术恢复后,所有动物都接受了延迟非匹配样本任务(DNMS)测试,这是一项识别记忆测试。交叉肢体裂脑组(CFHS)在DNMS中的获得(规则学习)和延迟表现(识别记忆)都明显受损。研究结果证明,内侧颞叶和背外侧前额叶皮层在学习和记忆中存在功能依赖性相互作用。(PsycInfo Database Record (c) 2023 APA, 版权所有)。
Prefrontal and medial temporal interactions in memory functions in the rhesus monkey.
Both the medial temporal lobe and the dorsolateral prefrontal cortex have been implicated in learning and memory. However, it has been difficult to ascertain the degree to which the two structures are dependent on each other or interact in subserving these cognitive functions. To investigate this question directly, we prepared two group of monkeys. First, the contralateral frontal-hippocampal split group (CFHS) received a unilateral lesion of the hippocampus and surrounding posterior parahippocampal cortices (H +), combined with a contralateral lesion of the dorsolateral prefrontal cortex (DLPFC) plus transection of the corpus callosum and anterior commissure. This preparation functionally "disconnects" the remaining intact H + from the sole intact DLPFC in the opposite hemisphere. As a surgical control group, a second set of animals, the ipsilateral frontal-hippocampal split group, was prepared with a unilateral lesion of the DLPFC and an ipsilateral H + lesion together plus transection of the corpus callosum and anterior commissure. This preparation matches the locus and extent of damage in the cross-lesion group but allows the intact H + and intact DLPFC to interact ipsilaterally. Following recovery from surgery, all animals were then tested on the delayed nonmatching to sample task (DNMS), a test of recognition memory. The crossed-lesion split-brain group (CFHS) was markedly impaired on DNMS in both acquisition (rule learning) and performance over delays (recognition memory). The results provide evidence of a functionally dependent interaction between the medial temporal lobe and the dorsolateral prefrontal cortex in learning and memory. (PsycInfo Database Record (c) 2023 APA, all rights reserved).