通过 16S rRNA 基因测序揭示肾移植受者肠道微生物群导致的胆汁酸代谢差异。

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-05-19 DOI:10.1080/13813455.2023.2212331
Xiaoqiang Wu, Xiangyong Tian, Guanghui Cao, Zhiwei Wang, Xuan Wu, Yue Gu, Tianzhong Yan
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引用次数: 0

摘要

本研究试图描述肾移植受试者和健康对照组受试者肠道微生物群的特征,以确定不同的肠道微生物群并分析其潜在功能。我们发现,两组受试者的肠道微生物群丰度存在显著差异。线性判别分析(LDA)效应大小(LEfSe)分析表明,细菌类群在两组间存在差异,肾移植受者不同分类水平的潜在生物标志物是链球菌、肠球菌科和反刍球菌。通过重建未观察到的状态(PICRUSt)对群落进行系统发育调查的功能推断分析表明,两组间肠道微生物群的差异与胆汁酸代谢有关。总之,两组间肠道微生物群丰度不同,与胆汁酸代谢有关,可能会影响异体移植受者的代谢平衡。
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Distinct profiles of bile acid metabolism caused by gut microbiota in kidney transplantation recipients revealed by 16S rRNA gene sequencing.

The present study sought to characterise the gut microbiota of subjects with kidney transplantation and healthy control to identify the distinct gut microbiota and analyse their potential function. We found that gut microbiota abundance had significant differences in subjects between the two groups. Line Discriminant Analysis (LDA) Effect Size (LEfSe) analysis showed that the bacterial taxa were differentially represented between the two groups, and the potential biomarkers at different taxonomic levels in kidney transplant recipients were Streptococcus, Enterococcaceae, and Ruminococcus. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) Functional Inference analyses suggested that the difference in gut microbiota between the two groups was correlated with bile acid metabolism. In conclusion, gut microbiota abundance is different between the two groups, which is related to bile acid metabolism, and may influence the metabolic homeostasis of allograft recipients.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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