免疫衰老、炎症和衰弱:骨髓细胞在年龄相关疾病中的作用。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2023-04-01 Epub Date: 2022-01-15 DOI:10.1007/s12016-021-08909-7
Augusto Bleve, Francesca Motta, Barbara Durante, Chiara Pandolfo, Carlo Selmi, Antonio Sica
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引用次数: 30

摘要

免疫系统是组织稳态的中心调节器,确保组织再生并保护其免受病原体和癌症细胞的新生。它的正常功能需要稳态特性,而稳态特性是通过骨髓和淋巴反应的充分平衡来维持的。衰老会逐渐破坏这种能力,并损害免疫反应的正确激活以及炎症反应的解决。“稳态虚弱”的亚临床综合征是老年人的一个独特特征,易患免疫衰弱和慢性低度炎症(炎症),导致慢性和退行性疾病的失控发展。先天免疫区室尤其会经历年龄依赖性功能改变的后遗症,包括骨髓祖细胞分化的步骤和对内源性和外源性威胁的反应改变。在这里,我们将回顾骨髓细胞群体的年龄依赖性进化,以及它们对老年人虚弱和疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases.

The immune system is the central regulator of tissue homeostasis, ensuring tissue regeneration and protection against both pathogens and the neoformation of cancer cells. Its proper functioning requires homeostatic properties, which are maintained by an adequate balance of myeloid and lymphoid responses. Aging progressively undermines this ability and compromises the correct activation of immune responses, as well as the resolution of the inflammatory response. A subclinical syndrome of "homeostatic frailty" appears as a distinctive trait of the elderly, which predisposes to immune debilitation and chronic low-grade inflammation (inflammaging), causing the uncontrolled development of chronic and degenerative diseases. The innate immune compartment, in particular, undergoes to a sequela of age-dependent functional alterations, encompassing steps of myeloid progenitor differentiation and altered responses to endogenous and exogenous threats. Here, we will review the age-dependent evolution of myeloid populations, as well as their impact on frailty and diseases of the elderly.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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