生物钟与炎症性肠病的关系

IF 2.1 Q3 CLINICAL NEUROLOGY Clocks & Sleep Pub Date : 2023-05-12 DOI:10.3390/clockssleep5020021
Jonathan Giebfried, Axel Lorentz
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引用次数: 1

摘要

生物钟是一种分子振荡器,它根据地球自转产生24小时的节律。炎症性肠病(IBD)等生理功能和病理生理过程与分子钟密切相关。本文综述了14项关于人体和小鼠生物钟与IBD相互作用的研究。这为IBD对核心时钟基因表达、代谢和免疫功能的负面影响提供了证据。另一方面,生物钟的紊乱会促进炎症。时钟基因的过度表达可导致炎症过程的抑制,而时钟基因的沉默可导致不可逆转的疾病活动。在人类和小鼠研究中,IBD和昼夜节律已被证明是相互影响的。需要进一步的研究来了解确切的机制,并开发潜在的心律相关疗法来改善IBD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Relationship between the Biological Clock and Inflammatory Bowel Disease.

The biological clock is a molecular oscillator that generates a 24-hour rhythm in accordance with the earth's rotation. Physiological functions and pathophysiological processes such as inflammatory bowel diseases (IBD) are closely linked to the molecular clock. This review summarizes 14 studies in humans and mice on the interactions between the biological clock and IBD. It provides evidence that IBD negatively affect core clock gene expression, metabolism and immune functions. On the other hand, disruption of the clock promotes inflammation. Overexpression of clock genes can lead to inhibition of inflammatory processes, while silencing of clock genes can lead to irreversible disease activity. In both human and mouse studies, IBD and circadian rhythms have been shown to influence each other. Further research is needed to understand the exact mechanisms and to develop potential rhythm-related therapies to improve IBD.

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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
7 weeks
期刊最新文献
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