突变诱导的DNA甲基化导致的CpG岛免疫丧失。

IF 3.5 2区生物学 Q1 GENETICS & HEREDITY Epigenetics & Chromatin Pub Date : 2023-05-11 DOI:10.1186/s13072-023-00488-5

Bernhard Horsthemke, Adrian Bird

{"title":"突变诱导的DNA甲基化导致的CpG岛免疫丧失。","authors":"Bernhard Horsthemke, Adrian Bird","doi":"10.1186/s13072-023-00488-5","DOIUrl":null,"url":null,"abstract":"The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715-731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be transmitted across generations, even after removal of the foreign DNA. These results were interpreted as evidence for transgenerational inheritance of acquired DNA methylation patterns. Here, we discuss several interpretational issues raised by this study and consider alternative explanations.","PeriodicalId":49253,"journal":{"name":"Epigenetics & Chromatin","volume":"16 1","pages":"17"},"PeriodicalIF":3.5000,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173581/pdf/","citationCount":"2","resultStr":"{\"title\":\"Loss of CpG island immunity to DNA methylation induced by mutation.\",\"authors\":\"Bernhard Horsthemke, Adrian Bird\",\"doi\":\"10.1186/s13072-023-00488-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715-731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be transmitted across generations, even after removal of the foreign DNA. These results were interpreted as evidence for transgenerational inheritance of acquired DNA methylation patterns. Here, we discuss several interpretational issues raised by this study and consider alternative explanations.\",\"PeriodicalId\":49253,\"journal\":{\"name\":\"Epigenetics & Chromatin\",\"volume\":\"16 1\",\"pages\":\"17\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2023-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173581/pdf/\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epigenetics & Chromatin\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1186/s13072-023-00488-5\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenetics & Chromatin","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s13072-023-00488-5","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 2

摘要

哺乳动物获得性性状的遗传是生物学中一个极具争议的话题。最近，Takahashi等人(Cell 186:715- 731,2023)报道，将无CpG的DNA插入CpG岛(CGI)可以诱导CGI的DNA甲基化，并且这种异常甲基化模式可以跨代传递，即使在去除外源DNA后也是如此。这些结果被解释为获得性DNA甲基化模式跨代遗传的证据。在这里，我们讨论了本研究提出的几个解释性问题，并考虑了其他解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Loss of CpG island immunity to DNA methylation induced by mutation.

The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715-731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be transmitted across generations, even after removal of the foreign DNA. These results were interpreted as evidence for transgenerational inheritance of acquired DNA methylation patterns. Here, we discuss several interpretational issues raised by this study and consider alternative explanations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Epigenetics & Chromatin GENETICS & HEREDITY-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.