Feasibility of high-yield plateletpheresis in routine practice: Experience from tertiary health center from South India.

Background and objectives: High-yield plateletpheresis donations can reduce donor exposure and be economically beneficial as well. However, obtaining a high-yield plateletpheresis from a maximum number of donors with low basal platelet count and its effect on postdonation platelet count of donors undergoing high-yield plateletpheresis has been a matter of concern. This study aimed to assess the feasibility of making high-yield platelet donation as a routine practice.

Methods: It was a retrospective observational study to determine the effect of high-yield plateletpheresis on donor reactions, efficacy, and quality parameters. It was conducted from January 1, 2019 to June 30, 2021, at the Department of Transfusion Medicine in a tertiary care hospital of South India.

Results: Out of the 669 procedures, 564 (84.3%) of the collection had a platelet yield of ≥5 × 10¹¹, 468 (70%) of the collection had a platelet yield of 5.5 × 10^11, whereas 284 (42.5%) met the target of 6 × 10¹¹ by coulter. The mean drops in platelet count were 95 ± 16 × 10³/μl (77,600-113,000/μl), mean platelet recruitment was 1.31 ± 0.51. The mean collection efficiency of the procedure for the 669 cases was shown to be 80.21 ± 15.34, and the mean collection rate was 0.07 × 10¹¹ ± 0.02 per minute. Only forty donors (5.5%) experienced adverse donor reactions.

Conclusions: High-yield plateletpheresis can be done in routine practice with no added adverse donor reaction with effective quality products.