Chiari II畸形胎儿期大脑发育异常。

IF 2.1 4区医学 Q1 ANATOMY & MORPHOLOGY Frontiers in Neuroanatomy Pub Date : 2023-04-17 eCollection Date: 2023-01-01 DOI:10.3389/fnana.2023.1116948

Olivia Masse, Emily Kraft, Esha Ahmad, Caitlin K Rollins, Clemente Velasco-Annis, Edward Yang, Simon Keith Warfield, Alireza A Shamshirsaz, Ali Gholipour, Henry A Feldman, Judy Estroff, Patricia Ellen Grant, Lana Vasung

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摘要

简介：Chiari II是一种相对常见的出生缺陷，与开放性脊柱异常有关，其特征是后窝内容物通过大孔向尾部迁移。Chiari II的病理生理学尚不完全清楚，后颅窝发现之外的神经生物学基础仍有待探索。我们的目的是确定17至26吉瓦的Chiari II胎儿大脑区域的变化。方法：我们使用了31个胎儿（6个对照组和25个Chiari II病例）的体内结构T2加权MRI。结果：与对照组相比，我们的研究结果表明，Chiari II畸形胎儿的间脑和增殖区（心室和室下区）的发育发生了变化。具体而言，患有Chiari II的胎儿间脑体积明显较小，侧脑室和增殖区体积明显较大。讨论：我们的结论是，在评估Chiari II胎儿的产前大脑发育时，应考虑区域大脑发育。

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Abnormal prenatal brain development in Chiari II malformation.

Introduction: The Chiari II is a relatively common birth defect that is associated with open spinal abnormalities and is characterized by caudal migration of the posterior fossa contents through the foramen magnum. The pathophysiology of Chiari II is not entirely known, and the neurobiological substrate beyond posterior fossa findings remains unexplored. We aimed to identify brain regions altered in Chiari II fetuses between 17 and 26 GW.

Methods: We used in vivo structural T2-weighted MRIs of 31 fetuses (6 controls and 25 cases with Chiari II).

Results: The results of our study indicated altered development of diencephalon and proliferative zones (ventricular and subventricular zones) in fetuses with a Chiari II malformation compared to controls. Specifically, fetuses with Chiari II showed significantly smaller volumes of the diencephalon and significantly larger volumes of lateral ventricles and proliferative zones.

Discussion: We conclude that regional brain development should be taken into consideration when evaluating prenatal brain development in fetuses with Chiari II.

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来源期刊

Frontiers in Neuroanatomy ANATOMY & MORPHOLOGY-NEUROSCIENCES

CiteScore

4.70

自引率

3.40%

发文量

122

审稿时长

>12 weeks

期刊介绍： Frontiers in Neuroanatomy publishes rigorously peer-reviewed research revealing important aspects of the anatomical organization of all nervous systems across all species. Specialty Chief Editor Javier DeFelipe at the Cajal Institute (CSIC) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.