抗逆转录病毒治疗的HIV感染者病毒学反弹状态的影响因素和不良结局

IF 3.5 4区医学 Q2 IMMUNOLOGY Journal of Virus Eradication Pub Date : 2023-03-01 DOI:10.1016/j.jve.2023.100320

Defu Yuan , Mingma Li , Ying Zhou , Lingen Shi , Jing Lu , Gengfeng Fu , Bei Wang

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引用次数: 2

摘要

抗逆转录病毒疗法（ART）旨在抑制HIV复制、减少CD4 T细胞损失和免疫功能恢复，以降低与感染相关的发病率和死亡率。治疗还应提高生活质量，控制艾滋病毒的传播。然而，在ART期间仍会出现不完全的病毒抑制。病毒抑制和病毒学失败（VF）阈值在使用不同检测阈值的病毒学反弹（VR）状态方面因研究而异。进一步了解不同VR状态的影响因素和不良后果，应为HIV治疗提供重要指导。

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Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection

Antiretroviral therapy (ART) aims to inhibit HIV replication, decrease CD4 T cell loss, and immune function recovery in order to reduce the morbidity and mortality associated with the infection. Treatment should also, improve quality of life and control HIV spread. However, incomplete viral suppression still occurs during ART. Viral suppression and virological failure (VF) thresholds vary between studies in terms of virological rebound (VR) states using different detection thresholds. Further understanding of influencing factors and adverse outcomes in various VR states should provide important guidance for HIV treatment.

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来源期刊

Journal of Virus Eradication Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.10

自引率

1.80%

发文量

审稿时长

39 weeks

期刊介绍： The Journal of Virus Eradication aims to provide a specialist, open-access forum to publish work in the rapidly developing field of virus eradication. The Journal covers all human viruses, in the context of new therapeutic strategies, as well as societal eradication of viral infections with preventive interventions. The Journal is aimed at the international community involved in the prevention and management of viral infections. It provides an academic forum for the publication of original research into viral reservoirs, viral persistence and virus eradication and ultimately development of cures. The Journal not only publishes original research, but provides an opportunity for opinions, reviews, case studies and comments on the published literature. It focusses on evidence-based medicine as the major thrust in the successful management of viral infections.The Journal encompasses virological, immunological, epidemiological, modelling, pharmacological, pre-clinical and in vitro, as well as clinical, data including but not limited to drugs, immunotherapy and gene therapy. It is an important source of information on the development of vaccine programs and preventative measures aimed at virus eradication.