Duygu Imre Yetkin, Esra Sizer, Yurdagül Tolu Gökhaner, Erkan Büyükdemirci, Abdullah Atlı
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引用次数: 0
摘要
目的:比较ASD患儿与对照组颈动脉内膜-中膜厚度(cIMT)、收缩期和舒张期直径(D)、内膜-中膜厚度/直径比(IDR)值，并分析这些参数与儿童自闭症评定量表(CARS)评分的相关性。方法:本前瞻性病例对照研究纳入37例诊断为ASD的儿童和38例未诊断为ASD的对照组。对ASD组超声测量结果与CARS评分的相关性进行评估。结果:ASD组右侧(ASD组中位:5.5 mm，对照组中位:5.1 mm)和左侧(ASD组中位:5.5 mm，对照组中位:5.1 mm)舒张直径均高于ASD组(p = 0.015, p = 0.032)。CARS评分与左cIMT、右cIMT、右cIMT/收缩期D、右cIMT/舒张期D、左cIMT/收缩期D、左cIMT/舒张期D呈显著相关(p)。结论:ASD患儿血管直径、cIMT、IDR值与CARS评分呈正相关，可作为ASD患儿早期动脉粥样硬化的标志。
Assessment of Sonographic Carotid Parameters in Autism Spectrum Disorder: A Comparative Case Control Study.
Objective: To compare carotid intima-media thickness (cIMT), systolic and diastolic diameters (D), intima-media thickness/diameter ratio (IDR) values in children with ASD, and control groups, and to analyze the correlation of these parameters with the Childhood Autism Rating Scale (CARS) scores.
Methods: This prospective case-control study included 37 children diagnosed with ASD and 38 individuals without ASD in the control group. Correlation assessments of sonographic measurements with CARS scores in the ASD group were also performed.
Results: Diastolic diameters of the right (median of ASD group:5.5 mm, control group:5.1 mm) and left (median of ASD group: 5.5 mm, in control group: 5.1 mm) side were higher in the ASD group (p = .015 and p = .032 respectively). A statistically significant correlation was detected between CARS score and left cIMT, right cIMT, right cIMT/systolic D, right cIMT/diastolic D, left cIMT/systolic D, and left cIMT/diastolic D (p < .05).
Conclusion: Vascular diameters, cIMT, and IDR values of children with ASD positively correlated with CARS scores, and these findings could be interpreted as a marker of early atherosclerosis in children with ASD.
期刊介绍：
Developmental Neurorehabilitation aims to enhance recovery, rehabilitation and education of people with brain injury, neurological disorders, and other developmental, physical and intellectual disabilities. Although there is an emphasis on childhood, developmental disability can be considered from a lifespan perspective. This perspective acknowledges that development occurs throughout a person’s life and thus a range of impairments or diseases can cause a disability that can affect development at any stage of life.
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