强迫症中错误的情感评价与神经错误加工。

IF 3.9 2区 医学 Q2 NEUROSCIENCES Social cognitive and affective neuroscience Pub Date : 2023-06-05 DOI:10.1093/scan/nsad022
Luisa Balzus, Franziska Jüres, Norbert Kathmann, Julia Klawohn
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引用次数: 0

摘要

尽管以错误相关负性(ERN)振幅增强为指标的过度主动错误监测是强迫症(OCD)的潜在生物标志物,但ERN振幅临床变化的机制尚不清楚。为了研究强迫症的ERN增强是否源于错误评价的改变,我们在28名强迫症患者和28名健康个体中检测了错误效价评价及其与ERN的关系。在情感启动范式中,在去/不去任务的反应之后是基于价值的词分类,记录了脑电图。结果表明,错误后对消极词的分类速度快于对积极词的分类速度,证实了错误的负效价。这种情感启动效应在强迫症患者中有所减少,而两组之间的表现是相当的。值得注意的是,这种减少随着症状严重程度的增加而扩大。这些结果表明强迫症患者的情感错误评价减弱,可能是由于焦虑的干扰作用。没有证据表明在效价评价和神经网络之间存在试验水平的关联,这意味着神经网络的振幅并不反映效价对误差的分配。因此,强迫症中错误监测的改变可能涉及不同过程的改变,其中之一是错误的负价分配较弱。
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Affective evaluation of errors and neural error processing in obsessive-compulsive disorder.

Even though overactive error monitoring, indexed by enhanced amplitudes of the error-related negativity (ERN), is a potential biomarker for obsessive-compulsive disorder (OCD), the mechanisms underlying clinical variations in ERN amplitude remain unknown. To investigate whether ERN enhancement in OCD results from altered error evaluation, we examined the trial-wise valence evaluation of errors and its relation to the ERN in 28 patients with OCD and 28 healthy individuals. Electroencephalogram was recorded during an affective priming paradigm in which responses in a go/no-go task were followed by valence-based word categorization. Results indicated that errors were followed by faster categorization of negative than positive words, confirming that negative valence is assigned to errors. This affective priming effect was reduced in patients with OCD, while go/no-go performance was comparable between groups. Notably, this reduction amplified with increasing symptom severity. These results suggest attenuated affective error evaluation in OCD, possibly resulting from interfering effects of anxiety. There was no evidence for a trial-level association between valence evaluation and ERN, implying that ERN amplitude does not reflect valence assignment to errors. Consequently, altered error monitoring in OCD may involve alterations in possibly distinct processes, with weaker assignment of negative valence to errors being one of them.

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来源期刊
CiteScore
6.80
自引率
4.80%
发文量
62
审稿时长
4-8 weeks
期刊介绍: SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.
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