肥胖与COVID-19住院时间之间的关系:来自美国心脏协会国家COVID-19登记处的意外见解。

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Journal of Obesity & Metabolic Syndrome Pub Date : 2022-09-30 DOI:10.7570/jomes22042
William J Collins, Andrew Y Chang, Yingjie Weng, Alex Dahlen, Connor G O'Brien, Jason Hom, Neera Ahuja, Fatima Rodriguez, Nidhi Rohatgi
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引用次数: 2

摘要

背景:肥胖与2019冠状病毒病(COVID-19)临床预后不良之间可能存在关联的机制尚不清楚。方法:我们使用美国心脏协会国家COVID-19登记处对2020年3月至2021年4月住院的22915例成人COVID-19患者进行非重症监护分析。采用多变量泊松模型调整年龄、性别、病史、入院呼吸状态、住院特征和实验室结果,计算住院时间(LOS)作为体重指数(BMI)的函数。我们同样分析了5,327名入住重症监护室的患者进行比较。结果:与BMI正常受试者相比,超重、I级肥胖和II级肥胖患者的LOS减少了大约半天(-0.469天)。结论:该模型发现,BMI类别与COVID-19的LOS之间存在剂量依赖的反比关系,而当该模型应用于危重患者时,则没有发现这种关系。
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Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry.

Background: The mechanism for possible association between obesity and poor clinical outcomes from Coronavirus Disease 2019 (COVID-19) remains unclear.

Methods: We analyzed 22,915 adult COVID-19 patients hospitalized from March 2020 to April 2021 to non-intensive care using the American Heart Association National COVID Registry. A multivariable Poisson model adjusted for age, sex, medical history, admission respiratory status, hospitalization characteristics, and laboratory findings was used to calculate length of stay (LOS) as a function of body mass index (BMI). We similarly analyzed 5,327 patients admitted to intensive care for comparison.

Results: Relative to normal BMI subjects, overweight, class I obese, and class II obese patients had approximately half-day reductions in LOS (-0.469 days, P<0.01; -0.480 days, P<0.01; -0.578 days, P<0.01, respectively).

Conclusion: The model identified a dose-dependent, inverse relationship between BMI category and LOS for COVID-19, which was not seen when the model was applied to critically ill patients.

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来源期刊
Journal of Obesity & Metabolic Syndrome
Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
8.30
自引率
9.60%
发文量
39
审稿时长
19 weeks
期刊介绍: The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).
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