单细胞分辨率的癌症特征蛋白质组学挖掘。

IF 6.9 2区 化学 Q1 SPECTROSCOPY Mass Spectrometry Reviews Pub Date : 2023-04-12 DOI:10.1002/mas.21842
Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou
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引用次数: 0

摘要

失调的蛋白质组是致癌的重要因素。蛋白质的波动助长了恶性转化的进展,如增殖失控、转移和化疗/放疗抗药性,严重影响了治疗效果,导致癌症患者疾病复发并最终死亡。癌症中普遍存在细胞异质性,已发现的众多细胞亚型对癌症的进展有很大影响。人群平均研究可能无法充分揭示异质性,从而得出不准确的结论。因此,深入挖掘单细胞分辨率的多重蛋白质组将为癌症生物学提供新的见解,从而开发预后生物标志物和治疗方法。考虑到单细胞蛋白质组学的最新进展,我们在此回顾了几项新技术,尤其是单细胞质谱分析技术,并总结了它们在癌症诊断和治疗中的优势和实际应用。单细胞蛋白质组学技术的发展将带来癌症检测、干预和治疗模式的转变。
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Proteomics mining of cancer hallmarks on a single-cell resolution

Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and numerous cell subtypes have been characterized that greatly influence cancer progression. Population-averaged research may not fully reveal the heterogeneity, leading to inaccurate conclusions. Thus, deep mining of the multiplex proteome at the single-cell resolution will provide new insights into cancer biology, to develop prognostic biomarkers and treatments. Considering the recent advances in single-cell proteomics, herein we review several novel technologies with particular focus on single-cell mass spectrometry analysis, and summarize their advantages and practical applications in the diagnosis and treatment for cancer. Technological development in single-cell proteomics will bring a paradigm shift in cancer detection, intervention, and therapy.

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来源期刊
Mass Spectrometry Reviews
Mass Spectrometry Reviews 物理-光谱学
CiteScore
16.30
自引率
3.00%
发文量
56
期刊介绍: The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.
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