Meilian Xie, Aiping Wang, Kerong Wang, Yanping Yu, Zhaoxia Lin
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The correlation trend and differences between PSS and HRQOL among asymptomatic and symptomatic PLWH were determined.</p><p><strong>Results: </strong>Information from 493 PLWH with ART medication was finally analyzed: 34.89% asymptomatic PLWH and 65.11% symptomatic PLWH. There were significant differences observed between the two groups in terms of family income (χ<sup>2</sup> = 9.782, P = 0.021), HIV-positive duration (χ<sup>2</sup> = 19.541, P < 0.001), stage of disease (χ<sup>2</sup> = 9.617, P = 0.008), and comorbidities (χ<sup>2</sup> = 26.119, P < 0.001). The mean score of HRQOL of PLWH for the whole domain of the questionnaire was 86.56 (SD = 15.95). In six domains of QOL and PSS, the asymptomatic group had better conditions than the symptomatic group. There was a linear association between PSS and HRQOL, not only in the symptomatic group but also asymptomatic population, after adjusting for potential confounding factors. When the level of PSS was between 60 and 80, the HRQOL of the symptomatic group was similar to that of the asymptomatic group. While the score of PSS exceeded 80, the HRQOL of the symptomatic group was less sensitive to the changes in PSS. The social and environmental status of HRQOL in PLWH was most strongly correlated with their PSS.</p><p><strong>Conclusion: </strong>The value of PSS on the HRQOL in PLWH is confirmed, especially for asymptomatic subjects. Healthcare providers need a complete understanding of the gap in social support between the asymptomatic and symptomatic populations. The comprehensive strategies, including symptom management, active treatment, and social support, should be more efficient for improving the overall health of symptomatic PLWH.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":"21 1","pages":"63-72"},"PeriodicalIF":0.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Perceived Social Support on Health-Related Quality of Life in Asymptomatic and Symptomatic People Living with HIV in China: A Cross-Sectional Study.\",\"authors\":\"Meilian Xie, Aiping Wang, Kerong Wang, Yanping Yu, Zhaoxia Lin\",\"doi\":\"10.2174/1570162X21666230123141922\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Improving health-related quality of life (HRQOL) in people living with HIV (PLWH) is one of the critical goals of HIV prevention and control in the following decades, and perceived social support (PSS) has always exhibited a positive influence on patients' HRQOL. This study aims to describe the gap in social support in improving HRQOL between symptomatic and asymptomatic PLWH.</p><p><strong>Methods: </strong>By analysing secondary data from an online survey, a multicenter, descriptive and crosssectional study was conducted. The correlation trend and differences between PSS and HRQOL among asymptomatic and symptomatic PLWH were determined.</p><p><strong>Results: </strong>Information from 493 PLWH with ART medication was finally analyzed: 34.89% asymptomatic PLWH and 65.11% symptomatic PLWH. There were significant differences observed between the two groups in terms of family income (χ<sup>2</sup> = 9.782, P = 0.021), HIV-positive duration (χ<sup>2</sup> = 19.541, P < 0.001), stage of disease (χ<sup>2</sup> = 9.617, P = 0.008), and comorbidities (χ<sup>2</sup> = 26.119, P < 0.001). The mean score of HRQOL of PLWH for the whole domain of the questionnaire was 86.56 (SD = 15.95). In six domains of QOL and PSS, the asymptomatic group had better conditions than the symptomatic group. There was a linear association between PSS and HRQOL, not only in the symptomatic group but also asymptomatic population, after adjusting for potential confounding factors. When the level of PSS was between 60 and 80, the HRQOL of the symptomatic group was similar to that of the asymptomatic group. While the score of PSS exceeded 80, the HRQOL of the symptomatic group was less sensitive to the changes in PSS. The social and environmental status of HRQOL in PLWH was most strongly correlated with their PSS.</p><p><strong>Conclusion: </strong>The value of PSS on the HRQOL in PLWH is confirmed, especially for asymptomatic subjects. Healthcare providers need a complete understanding of the gap in social support between the asymptomatic and symptomatic populations. 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引用次数: 0
摘要
目的:改善HIV感染者(PLWH)健康相关生活质量(HRQOL)是未来几十年HIV防控的重要目标之一，感知社会支持(PSS)一直对患者的HRQOL表现出积极的影响。本研究旨在描述社会支持在改善有症状和无症状PLWH患者HRQOL方面的差距。方法:通过分析在线调查的二手数据，进行多中心、描述性和横断面研究。比较无症状与有症状PLWH患者PSS与HRQOL的相关趋势及差异。结果:最终分析了493例接受抗逆转录病毒治疗的PLWH的信息:无症状PLWH占34.89%，有症状PLWH占65.11%。两组患者在家庭收入(χ2 = 9.782, P = 0.021)、hiv阳性持续时间(χ2 = 19.541, P < 0.001)、疾病分期(χ2 = 9.617, P = 0.008)、合并症(χ2 = 26.119, P < 0.001)方面差异均有统计学意义。调查全域PLWH患者HRQOL平均得分为86.56分(SD = 15.95)。在生活质量和PSS的6个方面，无症状组优于有症状组。在对潜在的混杂因素进行校正后，PSS与HRQOL之间不仅在有症状组，而且在无症状人群中均存在线性相关。PSS水平在60 ~ 80之间时，有症状组的HRQOL与无症状组相似。当PSS评分超过80分时，症状组HRQOL对PSS变化的敏感性较低。PLWH患者HRQOL的社会和环境状况与PSS相关性最强。结论:PSS对PLWH患者的HRQOL有一定的价值，尤其是对无症状患者。医疗保健提供者需要完全了解无症状人群和有症状人群在社会支持方面的差距。综合策略，包括症状管理、积极治疗和社会支持，应该更有效地改善有症状的PLWH的整体健康状况。
Effects of Perceived Social Support on Health-Related Quality of Life in Asymptomatic and Symptomatic People Living with HIV in China: A Cross-Sectional Study.
Objective: Improving health-related quality of life (HRQOL) in people living with HIV (PLWH) is one of the critical goals of HIV prevention and control in the following decades, and perceived social support (PSS) has always exhibited a positive influence on patients' HRQOL. This study aims to describe the gap in social support in improving HRQOL between symptomatic and asymptomatic PLWH.
Methods: By analysing secondary data from an online survey, a multicenter, descriptive and crosssectional study was conducted. The correlation trend and differences between PSS and HRQOL among asymptomatic and symptomatic PLWH were determined.
Results: Information from 493 PLWH with ART medication was finally analyzed: 34.89% asymptomatic PLWH and 65.11% symptomatic PLWH. There were significant differences observed between the two groups in terms of family income (χ2 = 9.782, P = 0.021), HIV-positive duration (χ2 = 19.541, P < 0.001), stage of disease (χ2 = 9.617, P = 0.008), and comorbidities (χ2 = 26.119, P < 0.001). The mean score of HRQOL of PLWH for the whole domain of the questionnaire was 86.56 (SD = 15.95). In six domains of QOL and PSS, the asymptomatic group had better conditions than the symptomatic group. There was a linear association between PSS and HRQOL, not only in the symptomatic group but also asymptomatic population, after adjusting for potential confounding factors. When the level of PSS was between 60 and 80, the HRQOL of the symptomatic group was similar to that of the asymptomatic group. While the score of PSS exceeded 80, the HRQOL of the symptomatic group was less sensitive to the changes in PSS. The social and environmental status of HRQOL in PLWH was most strongly correlated with their PSS.
Conclusion: The value of PSS on the HRQOL in PLWH is confirmed, especially for asymptomatic subjects. Healthcare providers need a complete understanding of the gap in social support between the asymptomatic and symptomatic populations. The comprehensive strategies, including symptom management, active treatment, and social support, should be more efficient for improving the overall health of symptomatic PLWH.
期刊介绍：
Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
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