原发性甲状腺淋巴瘤——附4例报告并文献复习。

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2023-01-01
Haoying Sun, Jinzhu Ma, Yibo Chen, Ming Liu
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引用次数: 0

摘要

目的:探讨原发性甲状腺淋巴瘤(primary thyroid lymphoma, PTL)的发病机制、临床特点、诊断、治疗及预后,提高对该病的认识,准确诊断PTL,防止误诊和误治。方法:回顾性分析2010年1月至2020年12月内蒙古医科大学附属医院甲状腺乳腺外科收治的4例PLT患者的临床表现、生化检查、超声检查、影像学检查、病理检查、诊断及治疗情况。结果:4例PTL患者均检测到表达CD20的弥漫性大b细胞淋巴瘤(DLBCL)。桥本甲状腺炎(HT)伴抗甲状腺球蛋白抗体(TGAb)升高2例,抗甲状腺过氧化物酶自身抗体(TPOAb)升高3例。所有4例患者均接受了手术和放化疗。随访8 ~ 55个月,均无肿瘤发生。结论:PTL是原发性甲状腺结外淋巴瘤,主要来源于b细胞非霍奇金淋巴瘤。PTL的发病机制尚不清楚,但与HT密切相关。本研究的临床诊断是通过针活检或手术切除来确定的。
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Primary thyroid lymphoma -- report of four cases and literature review.

Objective: This study aims to investigate the pathogenesis, clinical characteristics, diagnosis, treatment, and prognosis of primary thyroid lymphoma (PTL) for a better understanding of the disease and a more accurate PTL diagnosis, thereby preventing misdiagnosis and mistreatment.

Methods: The clinical manifestations, biochemical examination, ultrasound examination, imaging examination, pathologic examination, diagnosis, and treatment of four PLT patients admitted to the Department of Thyroid and Breast Surgery of the Affiliated Hospital of Inner Mongolia Medical University from January 2010 to December 2020 were retrospectively analyzed.

Results: Diffuse large B-cell lymphoma (DLBCL) expressing cluster of differentiation 20 (CD20) were detected in all four PTL patients. Hashimoto's thyroiditis (HT) with increased anti-thyroglobulin antibodies (TGAb) occurred in two PTL patients, while antithyroid peroxidase autoantibody (TPOAb) was increased in three cases. All four patients underwent surgical and chemoradiotherapy treatments. Patients were without tumors during the follow-up ranging from 8 to 55 months.

Conclusion: PTL is a primary extranodal lymphoma of the thyroid and is mainly derived from B-cell non-Hodgkin's lymphoma. The pathogenesis of PTL remains unclear, but it is closely related to HT. Clinical diagnosis in this study was determined by either needle biopsy or surgical resection.

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来源期刊
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发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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