番红花苷对电磁场诱导的氧化应激和小鼠肝肾损伤的改善作用。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-03-01 DOI:10.22038/AJP.2022.21169
Azam Vafaei, Ahmad Reza Raji, Mohsen Maleki, Mahdieh Zaeemi, Alireza Ebrahimzadeh-Bideskan
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引用次数: 0

摘要

目的:本研究的目的是研究番红花苷如何影响2100 MHz电磁场治疗小鼠的器官损伤,如肾脏和肝脏损伤。材料和方法:本研究使用暴露于电磁场的小鼠的肝脏和肾脏来检测番红花苷对它们的影响。24只雄性NMARI小鼠随机分为4组:EMF组(2100MHZ);Crocin(Cr)组(50mg/kg);EMF+Crocin组(2100MHZ+50mg/kg)和对照组。在实验后采集的血液样本中评估抗氧化酶和一些血清生化参数。动物入睡后,取肝脏和肾脏样本进行组织病理学分析,取肝脏样本进行超微结构分析。结果:EMF组血清尿素和肌酐水平、丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶活性均高于对照组,且差异有统计学意义。与对照组相比,EMF组的抗氧化剂(过氧化氢酶和超氧化物歧化酶)活性降低。与EMF组相比,EMF+Cr组的这些指标显著改善。EMF组的肝脏和肾脏存在不同的病理损伤,肝脏的超微结构发生了变化。Crocin管理减少了这些变化。结论:Crocin是一种抗氧化剂,可以通过减少氧化应激来防御EMF引起的组织损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.

Objective: The current study's goal was to examine how crocin affects organ damage such as damage to the kidney and liver in mice treated by 2100 MHz Electro Magnetic Field.

Materials and methods: The liver and kidneys of mice exposed to EMFs were used in this study to examine how crocin affected them. 24 male NMARI mice were randomly divided into 4 groups: EMF group (2100 MHZ); Crocin (Cr) group (50 mg/kg); EMF+Crocin group (2100 MHZ+50 mg/kg), and control group. The antioxidant enzymes and some serum biochemical parameters were assessed in blood samples collected after the experiment. After the animals were put to sleep, liver and kidney samples were taken for histopathological and liver samples were taken for ultrastructural analyses.

Results: The serum levels of urea and creatinine, and serum activities of alanine transaminase, aspartate transaminase, and alkaline phosphatase were higher in the EMF group than the control group, and this difference was significant. When compared to the control group, the EMF group's antioxidants, (catalase and superoxide dismutase) activity were decreased. These metrics significantly improved in the EMF + Cr group when compared to the EMF group. Different pathological damages were present in the liver and kidney of the EMF group, and the liver's ultrastructure had changed. Crocin administration decrease these changes.

Conclusion: Crocin, an antioxidant agent, may provide defense against tissue damage brought on by EMF by reducing oxidative stress.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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