乙酸 THC-O:迷幻大麻素的稀缺证据。

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-06-29 DOI:10.1080/02791072.2023.2230573
Daniel J Kruger, Carlton Cb Bone, Meredith C Meacham, Charles Klein, Jessica S Kruger
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引用次数: 0

摘要

人们对包括 THC-O-acetate (THC-Oac)在内的半合成大麻素的兴趣与日俱增。一些大麻销售商和使用者声称 THC-Oac 会产生迷幻效果;目前的研究是首次对这种说法进行研究。研究人员根据以往的大麻和迷幻药使用调查,并咨询了一个在线论坛的主持人,为 THC-Oac 消费者制定了一项在线调查。该调查评估了 THC-Oac 的体验特征,并包括神秘体验问卷 (MEQ) 中的项目,这是一种用于评估迷幻体验的工具。参与者报告的认知扭曲程度为中低水平(时间感改变、注意力难以集中、短期记忆困难),视觉或幻觉很少。在 MEQ 的所有四个维度上,参与者的回答都明显低于完整神秘体验的临界值。使用过经典(5-HT2A 激动剂)迷幻药的参与者在所有 MEQ 维度上的得分都较低。当被直接询问时,79%的人回答使用 THC-Oac 是 "完全没有 "或 "有一点 "迷幻体验。一些关于迷幻体验的报告可能是由于期望或污染物造成的。那些曾经使用过传统迷幻药的人对神秘体验的评价较低。
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THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid.

There is a growing interest in semi-synthetic cannabinoids, including THC-O-acetate (THC-Oac). Some cannabis marketers and users have claimed that THC-Oac produces psychedelic effects; the current study is the first to examine this claim. Researchers developed an online survey for THC-Oac consumers based on previous cannabis and psychedelic use surveys and in consultation with the moderator of an online forum. The survey assessed the experiential profile of THC-Oac and included items from the Mystical Experience Questionnaire (MEQ), an instrument for assessing psychedelic experiences. Participants reported a low to moderate level of cognitive distortions (altered sense of time, difficulties concentrating, difficulties with short-term memory) and few visuals or hallucinations. Participants' responses were significantly below the threshold for a complete mystical experience on all four MEQ dimensions. Participants who had used classic (5-HT2A agonist) psychedelics had lower scores on all MEQ dimensions. When asked directly, 79% responded that using THC-Oac is "not at all" or "a little" of a psychedelic experience. Some reports of psychedelic experiences may be due to expectations or contaminants. Those having prior experience with classic psychedelics had lower ratings of mystical experiences.

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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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