SUMO调控FKBP51活性与应激反应。

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of cellular biochemistry Pub Date : 2023-04-26 DOI:10.1002/jcb.30411

Romina P Gobbini, Vanina Giselle Velardo, Clara Sokn, Ana C Liberman, Eduardo Arzt

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引用次数: 1

摘要

糖皮质激素(GCs)的作用主要由核受体超家族成员GC受体(GR)介导。GR活性的改变与包括情绪障碍在内的不同疾病有关。FKBP51是一种GR伴侣蛋白，由于它是一种强的GR活性抑制剂而受到广泛关注。FKBP51在许多应激相关通路中发挥作用，可能是情绪行为的重要中介。参与调节应激反应和抗抑郁作用的关键蛋白由SUMOylation调节，SUMOylation是一种翻译后修饰，在神经元生理和疾病的调节中起重要作用。在这篇综述中，我们关注sumo偶联作为这一途径的调节因子的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SUMO regulation of FKBP51 activity and the stress response.

Glucocorticoids (GCs) actions are mostly mediated by the GC receptor (GR), a member of the nuclear receptor superfamily. Alterations of the GR activity have been associated to different diseases including mood disorders. FKBP51 is a GR chaperone that has gained much attention because it is a strong inhibitor of GR activity. FKBP51 exerts effects on many stress-related pathways and may be an important mediator of emotional behavior. Key proteins involved in the regulation of the stress response and antidepressant action are regulated by SUMOylation, a post-translational modification that has an important role in the regulation of neuronal physiology and disease. In this review, we focus on the role of SUMO-conjugation as a regulator of this pathway.

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来源期刊

Journal of cellular biochemistry 生物-生化与分子生物学

CiteScore

9.90

自引率

0.00%

发文量

164

审稿时长

1 months

期刊介绍： The Journal of Cellular Biochemistry publishes descriptions of original research in which complex cellular, pathogenic, clinical, or animal model systems are studied by biochemical, molecular, genetic, epigenetic or quantitative ultrastructural approaches. Submission of papers reporting genomic, proteomic, bioinformatics and systems biology approaches to identify and characterize parameters of biological control in a cellular context are encouraged. The areas covered include, but are not restricted to, conditions, agents, regulatory networks, or differentiation states that influence structure, cell cycle & growth control, structure-function relationships.