病毒是一个群落:负义RNA病毒种群的多样性。

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2022-09-21 DOI:10.1128/mmbr.00086-21
Lavinia J González Aparicio, Carolina B López, Sébastien A Felt
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引用次数: 5

摘要

负义RNA病毒群由不同的病毒成分组成,它们相互作用形成一个群落,并形成病毒感染的结果。在基因组水平上,RNA病毒种群不仅包括标准病毒基因组的同质种群,还包括数量极大的基因组变体,称为病毒准种和非标准病毒基因组,其中包括复制回病毒基因组、缺失病毒基因组、迷你病毒RNA和超突变RNA。在颗粒水平上,RNA病毒群体由多形性颗粒、缺失或具有额外基因组的颗粒、单颗粒或颗粒聚集体组成。随着我们对负义RNA病毒群体的组成成分及其在病毒感染过程中的关键功能的进一步了解,将RNA病毒群体作为一个整体而不是单个部分进行研究将变得更加重要。在这篇综述中,我们将讨论已知的负义RNA病毒群落的成分,推测病毒群落的成分如何相互作用,并总结目前正在开发的针对或利用这些成分的疫苗和抗病毒疗法。
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A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.

Negative-sense RNA virus populations are composed of diverse viral components that interact to form a community and shape the outcome of virus infections. At the genomic level, RNA virus populations consist not only of a homogeneous population of standard viral genomes but also of an extremely large number of genome variants, termed viral quasispecies, and nonstandard viral genomes, which include copy-back viral genomes, deletion viral genomes, mini viral RNAs, and hypermutated RNAs. At the particle level, RNA virus populations are composed of pleomorphic particles, particles missing or having additional genomes, and single particles or particle aggregates. As we continue discovering more about the components of negative-sense RNA virus populations and their crucial functions during virus infection, it will become more important to study RNA virus populations as a whole rather than their individual parts. In this review, we will discuss what is known about the components of negative-sense RNA virus communities, speculate how the components of the virus community interact, and summarize what vaccines and antiviral therapies are being currently developed to target or harness these components.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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