{"title":"白细胞中 Y 染色体的马赛克缺失：对男性健康的影响","authors":"Soichi Sano, Mark C Thel, Kenneth Walsh","doi":"10.1152/physiol.00008.2023","DOIUrl":null,"url":null,"abstract":"<p><p>We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"38 4","pages":"0"},"PeriodicalIF":5.3000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281780/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.\",\"authors\":\"Soichi Sano, Mark C Thel, Kenneth Walsh\",\"doi\":\"10.1152/physiol.00008.2023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.</p>\",\"PeriodicalId\":49694,\"journal\":{\"name\":\"Physiology\",\"volume\":\"38 4\",\"pages\":\"0\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281780/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/physiol.00008.2023\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/physiol.00008.2023","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
我们简要介绍了血液中的 Y 染色体缺失（LOY），并描述了这种情况的已知风险因素。然后，我们概述了 LOY 与年龄相关疾病特征之间的关联。最后，我们讨论了小鼠模型和 LOY 导致疾病的潜在机制。
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.
We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.
期刊介绍：
Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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