美国成年人全国代表性样本中的环境镍暴露与心血管疾病。

IF 4.5 3区 环境科学与生态学 Q1 WATER RESOURCES Exposure and Health Pub Date : 2023-06-08 DOI:10.1007/s12403-023-00579-4
Joshua Cheek, Sara Shuger Fox, Hans-Joachim Lehmler, Tyler J Titcomb
{"title":"美国成年人全国代表性样本中的环境镍暴露与心血管疾病。","authors":"Joshua Cheek, Sara Shuger Fox, Hans-Joachim Lehmler, Tyler J Titcomb","doi":"10.1007/s12403-023-00579-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association.</p><p><strong>Objective: </strong>This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults.</p><p><strong>Methods: </strong>Data from a nationally representative sample (<i>n</i> = 2702) in the National Health and Nutrition Examination Survey 2017-20 were used. CVD (<i>n</i> = 326) was defined as self-reported physicians' diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD.</p><p><strong>Results: </strong>Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73-7.36) for the second quartile, 3.61 (1.83-7.13) for the third quartile, and 2.40 (1.03-5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (P<sub>nonlinearity</sub> < 0.001).</p><p><strong>Conclusions: </strong>Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-023-00579-4.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":null,"pages":null},"PeriodicalIF":4.5000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249564/pdf/","citationCount":"1","resultStr":"{\"title\":\"<b>Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S.</b> Adults.\",\"authors\":\"Joshua Cheek, Sara Shuger Fox, Hans-Joachim Lehmler, Tyler J Titcomb\",\"doi\":\"10.1007/s12403-023-00579-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association.</p><p><strong>Objective: </strong>This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults.</p><p><strong>Methods: </strong>Data from a nationally representative sample (<i>n</i> = 2702) in the National Health and Nutrition Examination Survey 2017-20 were used. CVD (<i>n</i> = 326) was defined as self-reported physicians' diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD.</p><p><strong>Results: </strong>Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73-7.36) for the second quartile, 3.61 (1.83-7.13) for the third quartile, and 2.40 (1.03-5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (P<sub>nonlinearity</sub> < 0.001).</p><p><strong>Conclusions: </strong>Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-023-00579-4.</p>\",\"PeriodicalId\":12116,\"journal\":{\"name\":\"Exposure and Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2023-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249564/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exposure and Health\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1007/s12403-023-00579-4\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"WATER RESOURCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exposure and Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s12403-023-00579-4","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"WATER RESOURCES","Score":null,"Total":0}
引用次数: 1

摘要

背景:实验室研究已将镍与心血管疾病(CVD)的发病机制联系起来;然而,很少有对人类的观察性研究证实这种联系。目的:本研究旨在使用尿镍浓度作为环境镍暴露的生物标志物,在具有全国代表性的美国成年人样本中评估镍暴露与CVD之间的横断面关联。方法:来自全国代表性样本的数据(n = 2702)。CVD(n = 326)被定义为医生对冠心病、心绞痛、心脏病发作或中风的自我报告诊断。采用电感耦合等离子体质谱法测定尿中镍的浓度。使用样本权重的Logistic回归来估计CVD的优势比(OR)和95%置信区间(CI)。结果:患有CVD的个体的尿镍浓度(加权中位数1.34μg/L)高于没有CVD的个体(1.08μg/L)。在调整了CVD的人口统计学、社会经济、生活方式和其他风险因素后,CVD的OR(95%CI)与尿镍最低四分位数相比,第二个四分位数为3.57(1.73-7.36),第三个四分位为3.61(1.83-7.13),第四个四分位为2.40(1.03-5.59)。三次样条回归揭示了尿镍与CVD之间的非单调、反U型关联(P非线性 结论:在美国成年人中,镍暴露以非单调的方式与CVD相关,与众所周知的CVD风险因素无关。补充信息:在线版本包含补充材料,可访问10.1007/s12403-023-00579-4。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults.

Background: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association.

Objective: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults.

Methods: Data from a nationally representative sample (n = 2702) in the National Health and Nutrition Examination Survey 2017-20 were used. CVD (n = 326) was defined as self-reported physicians' diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD.

Results: Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73-7.36) for the second quartile, 3.61 (1.83-7.13) for the third quartile, and 2.40 (1.03-5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (Pnonlinearity < 0.001).

Conclusions: Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00579-4.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Exposure and Health
Exposure and Health Environmental Science-Pollution
CiteScore
13.80
自引率
9.00%
发文量
71
期刊介绍: It is a multidisciplinary journal focused on global human health consequences of exposure to water pollution in natural and engineered environments. The journal provides a unique platform for scientists in this field to exchange ideas and share information on research for the solution of health effects of exposure to water pollution. Coverage encompasses Engineering sciences; Biogeochemical sciences; Health sciences; Exposure analysis and Epidemiology; Social sciences and public policy; Mathematical, numerical and statistical methods; Experimental, data collection and data analysis methods and more. Research topics include local, regional and global water pollution, exposure and health problems; health risk analysis of water pollution, methods of quantification and analysis of risk under uncertainty; aquatic biogeochemical processes in natural and engineered systems and health effects; analysis of pollution, exposure and health data; and more.
期刊最新文献
Urinary Concentrations of BPA and Analogous Bisphenols (BPF and BPS) among School Children from Poland: Exposure and Risk Assessment in the REPRO_PL Cohort Soil Indigenous Microbes Interact with Maize Plants in High-Arsenic Soils to Limit the Translocation of Inorganic Arsenic Species to Maize Upper Tissues Screening of Micro-organic Compounds in Groundwater from Areas with Chronic Kidney Disease of Unclear Aetiology (CKDu) in the Dry Zone of Sri Lanka Assessment of Exposure to Synthetic Pyrethroids with the Use of Silicone Wristbands and Biomonitoring of Urinary Metabolites: A Pilot Study Associations Between Organophosphate Esters Exposure and Metabolic Syndrome: Exploring the Mediating Role of Oxidative Stress and Inflammation in Adults
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1