美国成年人全国代表性样本中的环境镍暴露与心血管疾病。

IF 4.5 3区 环境科学与生态学 Q1 WATER RESOURCES Exposure and Health Pub Date : 2023-06-08 DOI:10.1007/s12403-023-00579-4
Joshua Cheek, Sara Shuger Fox, Hans-Joachim Lehmler, Tyler J Titcomb
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引用次数: 1

摘要

背景:实验室研究已将镍与心血管疾病(CVD)的发病机制联系起来;然而,很少有对人类的观察性研究证实这种联系。目的:本研究旨在使用尿镍浓度作为环境镍暴露的生物标志物,在具有全国代表性的美国成年人样本中评估镍暴露与CVD之间的横断面关联。方法:来自全国代表性样本的数据(n = 2702)。CVD(n = 326)被定义为医生对冠心病、心绞痛、心脏病发作或中风的自我报告诊断。采用电感耦合等离子体质谱法测定尿中镍的浓度。使用样本权重的Logistic回归来估计CVD的优势比(OR)和95%置信区间(CI)。结果:患有CVD的个体的尿镍浓度(加权中位数1.34μg/L)高于没有CVD的个体(1.08μg/L)。在调整了CVD的人口统计学、社会经济、生活方式和其他风险因素后,CVD的OR(95%CI)与尿镍最低四分位数相比,第二个四分位数为3.57(1.73-7.36),第三个四分位为3.61(1.83-7.13),第四个四分位为2.40(1.03-5.59)。三次样条回归揭示了尿镍与CVD之间的非单调、反U型关联(P非线性 结论:在美国成年人中,镍暴露以非单调的方式与CVD相关,与众所周知的CVD风险因素无关。补充信息:在线版本包含补充材料,可访问10.1007/s12403-023-00579-4。
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Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults.

Background: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association.

Objective: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults.

Methods: Data from a nationally representative sample (n = 2702) in the National Health and Nutrition Examination Survey 2017-20 were used. CVD (n = 326) was defined as self-reported physicians' diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD.

Results: Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73-7.36) for the second quartile, 3.61 (1.83-7.13) for the third quartile, and 2.40 (1.03-5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (Pnonlinearity < 0.001).

Conclusions: Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00579-4.

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来源期刊
Exposure and Health
Exposure and Health Environmental Science-Pollution
CiteScore
13.80
自引率
9.00%
发文量
71
期刊介绍: It is a multidisciplinary journal focused on global human health consequences of exposure to water pollution in natural and engineered environments. The journal provides a unique platform for scientists in this field to exchange ideas and share information on research for the solution of health effects of exposure to water pollution. Coverage encompasses Engineering sciences; Biogeochemical sciences; Health sciences; Exposure analysis and Epidemiology; Social sciences and public policy; Mathematical, numerical and statistical methods; Experimental, data collection and data analysis methods and more. Research topics include local, regional and global water pollution, exposure and health problems; health risk analysis of water pollution, methods of quantification and analysis of risk under uncertainty; aquatic biogeochemical processes in natural and engineered systems and health effects; analysis of pollution, exposure and health data; and more.
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