黄酮类、异黄酮类和其他生物活性物质对胰岛素的增敏作用。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-01-01 DOI:10.2174/1573399819666230427095200
Kushagra Goswami, Badruddeen, Muhammad Arif, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahmad
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引用次数: 0

摘要

糖尿病是一种慢性病,对世界上很大一部分地区都有影响。事实证明,动物和人类都能从天然物品和生物(动物或微生物)中获益。2021 年,约有 5.37 亿成年人(20-79 岁)患有糖尿病,成为全球最大的死亡原因之一。各种植物成分保留了 β-细胞的活性,有助于预防糖尿病问题的形成。因此,β 细胞的质量和功能是关键的制药目标。本综述旨在概述类黄酮对胰腺β细胞的影响。研究表明,类黄酮能改善离体胰岛细胞系和糖尿病动物模型的胰岛素释放。类黄酮被认为可以通过抑制核因子-κB(NF-κB)信号传导、激活磷脂酰肌醇 3-激酶(PI3K)通路、抑制一氧化氮生成和降低活性氧水平来保护β细胞。类黄酮通过改善线粒体生物能功能和增加胰岛素分泌途径,提高β细胞的分泌能力。一些具有生物活性的植物成分,如 S-甲基半胱氨酸硫氧化物,能刺激体内胰岛素的合成,增加胰腺的输出量。小檗碱能增加 HIT-T15 和胰岛素瘤 6(MIN6)小鼠细胞系的胰岛素分泌。表没食子儿茶素-3-棓酸盐能防止细胞因子、活性氧(ROS)和高血糖引起的毒性。槲皮素已被证明能促进胰岛素瘤 1(INS-1)细胞产生胰岛素,还能保护细胞凋亡。总体而言,黄酮类化合物对β细胞有益,能防止其功能失调或降解,改善β细胞胰岛素的合成或释放。
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Flavonoids, Isoflavonoids and others Bioactives for Insulin Sensitizations.

Diabetes is a chronic condition that has an impact on a huge part of the world. Both animals and humans have been demonstrated to benefit from natural goods, and organisms (animals, or microbes). In 2021, approximately 537 million adults (20-79 years) are living with diabetes, making it the one of the biggest cause of death worldwide. Various phytoconstituent preserved β- cells activity helps to prevent the formation of diabetes problems. As a result, β-cells mass and function are key pharmaceutical targets. The purpose of this review is to provide an overview of flavonoids' effects on pancreatic β-cells. Flavonoids have been demonstrated to improve insulin release in cell lines of isolated pancreatic islets and diabetic animal models. Flavonoids are thought to protect β-cells by inhibiting nuclear factor-κB (NF-κB) signaling, activating the phosphatidylinositol 3-kinase (PI3K) pathway, inhibiting nitric oxide production, and lowering reactive oxygen species levels. Flavonoids boost β-cells secretory capacity by improving mitochondrial bioenergetic function and increasing insulin secretion pathways. Some of the bioactive phytoconstituents such as S-methyl cysteine sulfoxides stimulate insulin synthesis in the body and increase pancreatic output. The berberine increased insulin secretion in the HIT-T15 and Insulinoma 6 (MIN6) mouse cell line. Epigallocatechin-3-Gallate protects against toxicity accrued by cytokines, reactive oxygen species (ROS), and hyperglycemia. Quercetin has been proven to boost insulin production by Insulinoma 1 (INS-1) cells and also protect cell apoptosis. Overall flavonoids have beneficial effects on β-cells by prevented their malfunctioning or degradation and improving synthesis or release of insulin from β-cells.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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