自杀中毒与氯化汞。

IF 2.8 4区 医学 Q2 TOXICOLOGY Forensic Toxicology Pub Date : 2023-07-01 DOI:10.1007/s11419-022-00653-7
Sławomir Majdanik, Barbara Potocka-Banaś, Sebastian Glowinski, Sylwester Luzny
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引用次数: 3

摘要

目的:单质金属和金属化合物中毒在过去更为常见,除其他外,与生活方式和缺乏适当的毒理学诊断有关。一个例子是汞,它正在逐渐被淘汰,但仍有许多不同的应用,作为纯金属或以各种化合物的形式。本文介绍了一起氯化汞(腐蚀性升华剂)自杀中毒病例。方法:采用电感耦合等离子体质谱法(ICP-MS)进行法医学和毒理学试验。结果:患者死前有一系列症状,如胃脘痛、胃内容物呕吐、中枢性紫绀伴心动过速、震颤、严重呼吸短促伴喘息、吞咽困难、言语不清、肺部啰音和腹泻。ICP-MS测定的死前血样中汞浓度为191毫克/升,尸检血样中汞浓度为147毫克/升。两种浓度的汞都被认为是致命的。尸检显示在一些内脏器官有广泛的血栓性坏死迹象。结论:氯化汞的人体致死剂量估计在1至4克之间。它可产生一系列毒性作用,包括腐蚀性损伤、严重胃肠道紊乱、急性肾功能衰竭、循环衰竭和最终死亡。由于所使用的药剂类型,所提出的氯化汞致命中毒的案例现在在毒理学实践中很有趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Suicidal intoxication with mercury chloride.

Purpose: Poisoning with elemental metals and metallic compounds was much more frequent in the past, and was related, among other things, to lifestyle and the lack of appropriate toxicological diagnostics. One example is mercury, which is being gradually eliminated but still has many different applications as a pure metal or in the form of various compounds. The paper presents a case of suicidal poisoning with mercury chloride (corrosive sublimate).

Methods: Forensic and toxicological tests including inductively coupled plasma mass spectrometry (ICP-MS) were at the Department of Forensic Medicine, PMU in Szczecin.

Results: The patient before death had a range of symptoms such as epigastric pain, vomiting of the stomach contents, central cyanosis with tachycardia, tremors, severe shortness of breath with wheezing, difficulty swallowing, slurred speech, rales in the lungs, and diarrhea. The concentration of mercury measured by ICP-MS was 191 mg/L for a blood sample collected antemortem, and 147 mg/L for a blood sample collected at autopsy. Both concentrations of mercury are regarded as lethal. The post-mortem examination revealed signs of extensive thrombotic necrosis in some internal organs.

Conclusions: Mercuric chloride has an estimated human fatal dose of between 1 and 4 g. It can produce a range of toxic effects, including corrosive injury, severe gastrointestinal disturbances, acute renal failure, circulatory collapse, and eventual death. The presented case of fatal poisoning with mercury chloride, due to the type of agent used, is now interesting in toxicological practice.

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来源期刊
Forensic Toxicology
Forensic Toxicology TOXICOLOGY-
CiteScore
5.80
自引率
9.10%
发文量
40
审稿时长
3 months
期刊介绍: The journal Forensic Toxicology provides an international forum for publication of studies on toxic substances, drugs of abuse, doping agents, chemical warfare agents, and their metabolisms and analyses, which are related to laws and ethics. It includes original articles, reviews, mini-reviews, short communications, and case reports. Although a major focus of the journal is on the development or improvement of analytical methods for the above-mentioned chemicals in human matrices, appropriate studies with animal experiments are also published. Forensic Toxicology is the official publication of the Japanese Association of Forensic Toxicology (JAFT) and is the continuation of the Japanese Journal of Forensic Toxicology (ISSN 0915-9606).
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