幽门螺杆菌疫苗接种——癌症预防方法？

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Aspects of Medicine Pub Date : 2023-08-01 DOI:10.1016/j.mam.2023.101183

Verena Friedrich, Markus Gerhard

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引用次数: 0

摘要

革兰氏阴性菌幽门螺杆菌是最常见的慢性细菌感染，也是癌症的主要病因。由于幽门螺杆菌的抗微生物耐药性不断增加，开发有效的疫苗是预防疾病或感染并最终预防癌症的有效选择。然而，尽管进行了30多年的研究，但还没有疫苗进入市场。这篇综述强调了以前最相关的临床前和临床研究，以便得出结论，在未来需要特别关注哪些参数，以开发有效的幽门螺杆菌疫苗，从而预防癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vaccination against Helicobacter pylori – An approach for cancer prevention?

The gram-negative bacterium Helicobacter pylori is the most common chronic bacterial infection and the main cause of gastric cancer. Due to the increasing antimicrobial resistance of H. pylori, the development of an efficacious vaccine is a valid option to protect from disease or infection and ultimately prevent gastric cancer. However, despite more than 30 years of research, no vaccine has entered the market yet. This review highlights the most relevant previous preclinical and clinical studies to allow conclusions to be drawn on which parameters need special attention in the future to develop an efficacious vaccine against H. pylori and thus prevent gastric cancer.

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.