富含精氨酸肽的生物学特性及其在肿瘤转运中的应用。

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY Current drug delivery Pub Date : 2023-04-17 DOI:10.2174/1567201820666230417083350

Minghai Ma, Ruizhao Zhao, Xing Li, Minxuan Jing, Rundong Song, Jinhai Fan

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引用次数: 2

摘要

细胞穿透肽(CPPs)由少于30个氨基酸的短肽组成，富含精氨酸(Arg)或赖氨酸(Lys)。在过去的30年里，CPPs吸引了人们对各种货物(如药物、核酸和其他大分子)运输的兴趣。在所有类型的CPPs中，富含精氨酸的CPPs由于其胍基团与带负电荷的细胞成分之间的双齿结合而表现出更高的跨膜效率。此外，富含精氨酸的cps可以诱导内核体逃逸，以保护货物免受溶酶体依赖的降解。本文综述了富含精氨酸的CPPs的功能、设计原理和穿透机制，并概述了其在肿瘤药物传递和生物传感方面的生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological Properties of Arginine-rich Peptides and their Application in Cargo Delivery to Cancer.

Cell-penetrating peptides (CPPs) comprise short peptides of fewer than 30 amino acids, which are rich in arginine (Arg) or lysine (Lys). CPPs have attracted interest in the delivery of various cargos, such as drugs, nucleic acids, and other macromolecules over the last 30 years. Among all types of CPPs, arginine-rich CPPs exhibit higher transmembrane efficiency due to bidentate bonding between their guanidinium groups and negatively charged cellular components. Besides, endosome escape can be induced by arginine-rich CPPs to protect cargo from lysosome-dependent degradation. Here we summarize the function, design principles, and penetrating mechanisms of arginine-rich CPPs, and outline their biomedical applications in drug delivery and biosensing in tumors.

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.