热休克蛋白:连接先天免疫和乙肝病毒感染的双刃剑

IF 3.5 4区医学 Q2 IMMUNOLOGY Journal of Virus Eradication Pub Date : 2023-03-01 DOI:10.1016/j.jve.2023.100322

Wen-ying Dai , Guo-qing Yao , Xi-chuan Deng , Guang-chao Zang , Jia Liu , Guang-yuan Zhang , Yu-meng Chen , Ming-qi Lv , Ting-ting Chen

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引用次数: 2

摘要

热休克蛋白（HSPs）是应激蛋白家族之一，具有多种功能。近年来，有报道称它们在乙型肝炎病毒（HBV）中起双重作用，即与肝硬化和癌症相关的持续感染。在这篇文章中，我们总结了HSP与病毒，特别是HBV和相关疾病之间的调节机制，基于HSP对病毒感染的生物学功能。鉴于其作为广谱抗病毒靶点的潜力，我们还讨论了基于HSPs的药物开发的当前进展和挑战，以及已在HBV治疗中进行临床评估的药物的潜在应用。

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Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection

Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment.

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来源期刊

Journal of Virus Eradication Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.10

自引率

1.80%

发文量

审稿时长

39 weeks

期刊介绍： The Journal of Virus Eradication aims to provide a specialist, open-access forum to publish work in the rapidly developing field of virus eradication. The Journal covers all human viruses, in the context of new therapeutic strategies, as well as societal eradication of viral infections with preventive interventions. The Journal is aimed at the international community involved in the prevention and management of viral infections. It provides an academic forum for the publication of original research into viral reservoirs, viral persistence and virus eradication and ultimately development of cures. The Journal not only publishes original research, but provides an opportunity for opinions, reviews, case studies and comments on the published literature. It focusses on evidence-based medicine as the major thrust in the successful management of viral infections.The Journal encompasses virological, immunological, epidemiological, modelling, pharmacological, pre-clinical and in vitro, as well as clinical, data including but not limited to drugs, immunotherapy and gene therapy. It is an important source of information on the development of vaccine programs and preventative measures aimed at virus eradication.