在一项全球研究中,在五个地点对神经认知评估进行跨国协调。

IF 2.6 3区 心理学 Q3 NEUROSCIENCES Neuropsychology Pub Date : 2023-03-01 Epub Date: 2022-07-04 DOI:10.1037/neu0000838
Marcelo C Batistuzzo, Karthik Sheshachala, Daniel M Alschuler, Dianne M Hezel, Roberto Lewis-Fernández, Niels T de Joode, Chris Vriend, Karolina M Lempert, Madhuri Narayan, Clara Marincowitz, Christine Lochner, Dan J Stein, Janardhanan C Narayanaswamy, Odile A van den Heuvel, Helen Blair Simpson, Melanie Wall
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引用次数: 0

摘要

目的:跨国神经认知测试工作的特点是结果不一致,这表明需要加强协调。在此,我们介绍一项正在进行的全球合作研究中的前瞻性协调方法:方法:我们对来自巴西、印度、荷兰、南非和美国的 221 人进行了视觉空间 N-Back、伦敦塔(ToL)、停止信号任务(SST)、风险厌恶(RA)和时际选择(ITC)任务测试。我们采用了前瞻性协调方法,以确保不同地点的任务实施和衍生任务测量的处理过程具有相似性。在控制性别、年龄、教育程度和社会经济地位(SES)的前提下,采用广义线性模型对不同地点之间的差异进行了测试。此外,还检验了与这些协变量的关联,并检验了不同研究点之间的差异以及研究点与协变量之间的交互作用:除美国研究点的 N-Back 外,荷兰研究点在 N-Back 和 ToL 方面的表现比其他研究点更准确。荷兰和美国站点在 SST 去程事件中的表现快于其他三个站点。最后,在 ITC 任务中,荷兰研究点比其他研究点表现出更高的延迟折现容忍度;在 RA 任务中,印度研究点比其他研究点表现出更多的风险规避。然而,在剔除荷兰(ToL、N-Back、ITC 和 SST 任务)和印度(RA 任务)后,各研究点在五项任务上的效应大小差异普遍较小(即部分等方差小于 0.05)。在所有任务中,无论研究地点如何,N-Back(性别、年龄、教育程度和社会经济地位)、ToL(性别、年龄和社会经济地位)、SST(年龄)和 ITC(社会经济地位)都显示出与协变量的相关性:五个研究点中有四个研究点的每项任务在研究点之间的差异很小。然而,尽管我们采取了大量的前瞻性协调步骤,荷兰研究点(四项任务)和印度研究点(一项任务)的任务得分表现仍与其他研究点存在偏差。由于各研究点的程序方法都是标准化的,而且我们的分析对协变量进行了调整,因此认知表现上的差异可能是由于未测量的混杂因素导致的选择性抽样偏差。未来的研究在评估神经认知时应遵循类似的跨研究机构前瞻性统一程序,并考虑测量其他可能的混杂变量,以进行额外的统计控制。(PsycInfo Database Record (c) 2023 APA, 版权所有)。
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Cross-national harmonization of neurocognitive assessment across five sites in a global study.

Objective: Cross-national work on neurocognitive testing has been characterized by inconsistent findings, suggesting the need for improved harmonization. Here, we describe a prospective harmonization approach in an ongoing global collaborative study.

Method: Visuospatial N-Back, Tower of London (ToL), Stop Signal task (SST), Risk Aversion (RA), and Intertemporal Choice (ITC) tasks were administered to 221 individuals from Brazil, India, the Netherlands, South Africa, and the USA. Prospective harmonization methods were employed to ensure procedural similarity of task implementation and processing of derived task measures across sites. Generalized linear models tested for between-site differences controlling for sex, age, education, and socioeconomic status (SES). Associations with these covariates were also examined and tested for differences by site with site-by-covariate interactions.

Results: The Netherlands site performed more accurately on N-Back and ToL than the other sites, except for the USA site on the N-Back. The Netherlands and the USA sites performed faster than the other three sites during the go events in the SST. Finally, the Netherlands site also exhibited a higher tolerance for delay discounting than other sites on the ITC, and the India site showed more risk aversion than other sites on the RA task. However, effect size differences across sites on the five tasks were generally small (i.e., partial eta-squared < 0.05) after dropping the Netherlands (on ToL, N-Back, ITC, and SST tasks) and India (on the RA task). Across tasks, regardless of site, the N-Back (sex, age, education, and SES), ToL (sex, age, and SES), SST (age), and ITC (SES) showed associations with covariates.

Conclusions: Four out of the five sites showed only small between-site differences for each task. Nevertheless, despite our extensive prospective harmonization steps, task score performance deviated from the other sites in the Netherlands site (on four tasks) and the India site (on one task). Because the procedural methods were standardized across sites, and our analyses were adjusted for covariates, the differences found in cognitive performance may indicate selection sampling bias due to unmeasured confounders. Future studies should follow similar cross-site prospective harmonization procedures when assessing neurocognition and consider measuring other possible confounding variables for additional statistical control. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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来源期刊
Neuropsychology
Neuropsychology 医学-神经科学
CiteScore
4.10
自引率
4.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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