病毒感染过程中 RNase L 对核糖核蛋白缩聚物的调控

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-07-01 Epub Date: 2022-12-07 DOI:10.1002/wrna.1770
James M Burke
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引用次数: 0

摘要

在应对病毒感染时,哺乳动物细胞会激活几种先天性免疫途径来抑制病毒基因的表达。识别病毒双链 RNA 后,蛋白激酶 R(PKR)会使真核生物起始因子 2(eIF2α)α 亚基丝氨酸 51 发生磷酸化。这就抑制了典型的翻译启动,从而广泛地拮抗了病毒蛋白质的合成。它还能促进细胞质核糖核蛋白复合物(称为应激颗粒(SG))的组装。人们普遍认为 SGs 可促进细胞存活和抗病毒信号转导。然而,OAS/RNase L 抗病毒途径的共同激活会抑制 SGs 的组装,并促进称为 RNase L 依赖体(RLB)的另一种核糖核蛋白复合物的组装。在双链 RNA、登革热病毒感染或 SARS-CoV-2 感染时,可观察到 RLB 的形成。在此,我们回顾了 SGs 和 RLBs 不同的生物生成途径和特性,并对它们在抗病毒反应中的潜在功能进行了展望。本文归类于RNA 与蛋白质及其他分子的相互作用 > RNA 蛋白复合物 RNA 更替与监控 > RNA 稳定性调控 RNA 输出与定位 > RNA 定位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Regulation of ribonucleoprotein condensates by RNase L during viral infection.

In response to viral infection, mammalian cells activate several innate immune pathways to antagonize viral gene expression. Upon recognition of viral double-stranded RNA, protein kinase R (PKR) phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α) on serine 51. This inhibits canonical translation initiation, which broadly antagonizes viral protein synthesis. It also promotes the assembly of cytoplasmic ribonucleoprotein complexes termed stress granules (SGs). SGs are widely thought to promote cell survival and antiviral signaling. However, co-activation of the OAS/RNase L antiviral pathway inhibits the assembly of SGs and promotes the assembly of an alternative ribonucleoprotein complex termed an RNase L-dependent body (RLB). The formation of RLBs has been observed in response to double-stranded RNA, dengue virus infection, or SARS-CoV-2 infection. Herein, we review the distinct biogenesis pathways and properties of SGs and RLBs, and we provide perspective on their potential functions during the antiviral response. This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Turnover and Surveillance > Regulation of RNA Stability RNA Export and Localization > RNA Localization.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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