深部脑刺激治疗强迫症和抑郁症。

IF 12.1 1区 医学 Q1 NEUROSCIENCES Annual review of neuroscience Pub Date : 2023-07-10 DOI:10.1146/annurev-neuro-110122-110434
Sameer A Sheth, Helen S Mayberg
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引用次数: 4

摘要

立体定向神经外科领域在70多年前发展起来,以解决严重精神疾病患者的治疗差距。在此后的几十年里,得益于临床和基础科学的进步,它已经非常成熟。深部脑刺激(DBS)治疗严重的、难治性精神疾病目前正准备从经验主义阶段过渡到一个日益植根于科学发现的阶段。目前这种转变的驱动因素是神经影像学的进步,但迅速出现的是神经生理学——随着我们更多地了解这些疾病的神经基础,我们将能够更成功地使用干预措施,如侵入性刺激,来恢复功能失调的神经回路的健康。与这种转变并行的是结果数据的一致性和质量的稳步提高。在这里,我们关注强迫症和抑郁症,这两个主题在试验量和科学努力方面受到了最多的关注。
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Deep Brain Stimulation for Obsessive-Compulsive Disorder and Depression.

The field of stereotactic neurosurgery developed more than 70 years ago to address a therapy gap for patients with severe psychiatric disorders. In the decades since, it has matured tremendously, benefiting from advances in clinical and basic sciences. Deep brain stimulation (DBS) for severe, treatment-resistant psychiatric disorders is currently poised to transition from a stage of empiricism to one increasingly rooted in scientific discovery. Current drivers of this transition are advances in neuroimaging, but rapidly emerging ones are neurophysiological-as we understand more about the neural basis of these disorders, we will more successfully be able to use interventions such as invasive stimulation to restore dysfunctional circuits to health. Paralleling this transition is a steady increase in the consistency and quality of outcome data. Here, we focus on obsessive-compulsive disorder and depression, two topics that have received the most attention in terms of trial volume and scientific effort.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
期刊最新文献
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