一项前瞻性单盲随机临床试验比较两种治疗方案对轻度减压病的初始管理。

IF 0.8 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Diving and hyperbaric medicine Pub Date : 2022-06-30 DOI:10.28920/dhm52.2.85-91
Neil Banham, Philippa Hawkings, Ian Gawthrope
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引用次数: 1

摘要

有限的证据表明,较短的再压缩时间表可能与美国海军治疗表6 (USN TT6)一样有效,用于治疗轻度减压病(DCS)。本研究旨在确定潜水员轻度DCS是否可以有效地治疗短腔治疗台。方法:所有到弗里曼特尔医院高压医学部门就诊的疑似DCS的患者均被纳入评估。轻度DCS的参与者被随机分配,通过改进的USN TT6 (TT6m)或更短的定制治疗表(FH01)在单室中接受再压缩。主要结局是治疗的次数,直到缓解或没有进一步改善(平台期)。结果:DCS 41例,TT6m 21例,FH01 20例。分配到FH01组的2例患者由于未能显著改善(根据方案)而在治疗中期转移到TT6m, 2例TT6m需要延长。治疗FH01至症状缓解的中位总次数为1 (IQR 1-1), TT6m至症状缓解的中位总次数为2 (IQR 1-2) (P = 0.01)。FH01组患者(17/20,85%)在初始治疗后症状完全缓解,而TT6m组患者(8/21,38%)在初始治疗后症状完全缓解(P = 0.003)。FH01和TT6m的总体结局相似,分别有19/20和20/21在最终治疗结束时无症状(P = 0.97)。在所有进行了两周随访接触的病例中(n = 14 FH01和n = 12 TT6m),患者报告保持完全症状缓解。结论:FH01患者治疗至症状缓解的中位数总次数显著少于FH01患者,且治疗时间越短,初始治疗后症状完全缓解的情况越多。在治疗完成和随访时,患者的结果相似。我们得出结论,FH01在治疗轻度减压病方面优于TT6m。
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A prospective single-blind randomised clinical trial comparing two treatment tables for the initial management of mild decompression sickness.

Introduction: Limited evidence suggests that shorter recompression schedules may be as efficacious as the US Navy Treatment Table 6 (USN TT6) for treatment of milder presentations of decompression sickness (DCS). This study aimed to determine if divers with mild DCS could be effectively treated with a shorter chamber treatment table.

Methods: All patients presenting to the Fremantle Hospital Hyperbaric Medicine Unit with suspected DCS were assessed for inclusion. Participants with mild DCS were randomly allocated to receive recompression in a monoplace chamber via either a modified USN TT6 (TT6m) or a shorter, custom treatment table (FH01). The primary outcome was the number of treatments required until resolution or no further improvement (plateau).

Results: Forty-one DCS cases were included, 21 TT6m and 20 FH01. Two patients allocated to FH01 were moved to TT6m mid-treatment due to failure to significantly improve (as per protocol), and two TT6m required extensions. The median total number of treatments till symptom resolution was 1 (IQR 1-1) for FH01 and 2 (IQR 1-2) for TT6m (P = 0.01). More patients in the FH01 arm (17/20, 85%) showed complete symptom resolution after the initial treatment, versus 8/21 (38%) for TT6m (P = 0.003). Both FH01 and TT6m had similar overall outcomes, with 19/20 and 20/21 respectively asymptomatic at the completion of their final treatment (P = 0.97). In all cases where two-week follow-up contact was made, (n = 14 FH01 and n = 12 TT6m), patients reported maintaining full symptom resolution.

Conclusions: The median total number of treatments till symptom resolution was meaningfully fewer with FH01 and the shorter treatment more frequently resulted in complete symptom resolution after the initial treatment. There were similar patient outcomes at treatment completion, and at follow-up. We conclude that FH01 appears superior to TT6m for the treatment of mild decompression sickness.

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来源期刊
Diving and hyperbaric medicine
Diving and hyperbaric medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
1.70
自引率
22.20%
发文量
37
审稿时长
>12 weeks
期刊介绍: Diving and Hyperbaric Medicine (DHM) is the combined journal of the South Pacific Underwater Medicine Society (SPUMS) and the European Underwater and Baromedical Society (EUBS). It seeks to publish papers of high quality on all aspects of diving and hyperbaric medicine of interest to diving medical professionals, physicians of all specialties, scientists, members of the diving and hyperbaric industries, and divers. Manuscripts must be offered exclusively to Diving and Hyperbaric Medicine, unless clearly authenticated copyright exemption accompaniesthe manuscript. All manuscripts will be subject to peer review. Accepted contributions will also be subject to editing.
期刊最新文献
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