{"title":"【精氨酸加压素V2受体拮抗剂托伐普坦治疗肝硬化腹水的研究进展】。","authors":"Y Y Hu, X Zhang, Y D Wang, C Y Zhao","doi":"10.3760/cma.j.cn112138-20220630-00488","DOIUrl":null,"url":null,"abstract":"腹水是肝硬化常见且增加死亡风险的重要并发症之一。精氨酸加压素（AVP）V2受体拮抗剂托伐普坦（TLV）作为肝硬化腹水治疗的新型药物选择，尤其适合合并低钠血症患者，其作用疗效及安全性评价在多项研究中确立。但也有最新证据显示肝硬化合并难治性腹水患者使用TLV获益有限。本文将对TLV治疗肝硬化合并腹水的作用机制、疗效与安全性及应用策略进行综述，以期规范其在肝硬化合并腹水患者中的合理应用。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"881-884"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Research progress of arginine vasopressin V2 receptor antagonist tolvaptan in the treatment of cirrhotic ascites].\",\"authors\":\"Y Y Hu, X Zhang, Y D Wang, C Y Zhao\",\"doi\":\"10.3760/cma.j.cn112138-20220630-00488\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"腹水是肝硬化常见且增加死亡风险的重要并发症之一。精氨酸加压素（AVP）V2受体拮抗剂托伐普坦（TLV）作为肝硬化腹水治疗的新型药物选择，尤其适合合并低钠血症患者，其作用疗效及安全性评价在多项研究中确立。但也有最新证据显示肝硬化合并难治性腹水患者使用TLV获益有限。本文将对TLV治疗肝硬化合并腹水的作用机制、疗效与安全性及应用策略进行综述，以期规范其在肝硬化合并腹水患者中的合理应用。.\",\"PeriodicalId\":24000,\"journal\":{\"name\":\"Zhonghua nei ke za zhi\",\"volume\":\"62 7\",\"pages\":\"881-884\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua nei ke za zhi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112138-20220630-00488\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20220630-00488","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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